TOREFORANT
Toreforant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histamine H4 receptor.
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Commercial
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 3 | — | — | — | 4 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | 3 | — | — | — | 4 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TOREFORANT |
| INN | toreforant |
| Description | Toreforant (JNJ-38518168) is an orally-dosed selective antagonist of the histamine H4 receptor that has been studied for various health conditions. It is the successor of a number of H4-selective compounds developed by Johnson & Johnson. Phase IIa clinical trials completed as recently as November 2018 continue to suggest that toreforant is safe.
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| Classification | Small molecule |
| Drug class | histamine H4 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C)c2nc(-c3cnc(NCCCC4CCN(C)CC4)nc3C)[nH]c2c1 |
Identifiers
| PDB | — |
| CAS-ID | 952494-46-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301609 |
| ChEBI ID | — |
| PubChem CID | 23650961 |
| DrugBank | DB12522 |
| UNII ID | U6LA7G393X (ChemIDplus, GSRS) |
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Safety
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Adverse Events
0 adverse events reported
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