TOMIVOSERTIB
Tomivosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against MAP kinase-interacting serine/threonine-protein kinase 2 and MAP kinase-interacting serine/threonine-protein kinase 1. In addition, it is known to target serine/threonine-protein kinase 17A and dual specificity protein kinase CLK4.
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Commercial
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | — | 1 | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | 1 | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TOMIVOSERTIB |
| INN | tomivosertib |
| Description | Tomivosertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against MAP kinase-interacting serine/threonine-protein kinase 2 and MAP kinase-interacting serine/threonine-protein kinase 1. In addition, it is known to target serine/threonine-protein kinase 17A and dual specificity protein kinase CLK4. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 1849590-01-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4073443 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | U2H19X4WBV (ChemIDplus, GSRS) |
Target
Agency Approved
MKNK2
MKNK2
MKNK1
MKNK1
Organism
Homo sapiens
Gene name
MKNK2
Gene synonyms
GPRK7, MNK2
NCBI Gene ID
Protein name
MAP kinase-interacting serine/threonine-protein kinase 2
Protein synonyms
G protein-coupled receptor kinase 7, MAP kinase interacting serine/threonine kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2
Uniprot ID
Mouse ortholog
Mknk2 (17347)
MAP kinase-interacting serine/threonine-protein kinase 2 (Q9D893)
Alternate
STK17A
STK17A
CLK4
CLK4
Organism
Homo sapiens
Gene name
STK17A
Gene synonyms
DRAK1
NCBI Gene ID
Protein name
serine/threonine-protein kinase 17A
Protein synonyms
DAP kinase-related apoptosis-inducing protein kinase 1, death-associated protein kinase-related 1, serine/threonine kinase 17a (apoptosis-inducing)
Uniprot ID
Mouse ortholog
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Variants
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Safety
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Adverse Events
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