TALAMPANEL
Talampanel is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glutamate receptor 2.
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Commercial
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | — | 2 | — | — | — | 2 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 2 | — | — | — | 2 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 1 | — | — | — | 1 |
| Movement disorders | D009069 | EFO_0004280 | G25 | 1 | 1 | — | — | — | 1 |
| Dyskinesias | D020820 | — | G24 | 1 | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | 1 | — | — | — | 1 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | — | 1 | — | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TALAMPANEL |
| INN | talampanel |
| Description | Talampanel is a member of benzodioxoles. |
| Classification | Small molecule |
| Drug class | ionotropic non-NMDA (N-methyl D-aspartate) glutamate receptors [AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) and/or KA (kainite antagonist) receptors]: antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)N1N=C(c2ccc(N)cc2)c2cc3c(cc2C[C@H]1C)OCO3 |
Identifiers
| PDB | — |
| CAS-ID | 161832-65-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL61872 |
| ChEBI ID | 34992 |
| PubChem CID | 164509 |
| DrugBank | — |
| UNII ID | CVS43XG1L5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GRIA2
GRIA2
Organism
Homo sapiens
Gene name
GRIA2
Gene synonyms
GluA2, GLUR2
NCBI Gene ID
Protein name
glutamate receptor 2
Protein synonyms
AMPA receptor subunit GluA2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, glutamate receptor, ionotropic, AMPA 2
Uniprot ID
Mouse ortholog
Gria2 (14800)
glutamate receptor 2 (Q9D6D3)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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