TALADEGIB
Taladegib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein smoothened.
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Commercial
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 3 |
| Fibrosis | D005355 | — | — | 1 | 2 | — | — | — | 3 |
| Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | 1 | 2 | — | — | — | 3 |
| Pulmonary fibrosis | D011658 | — | — | 1 | 2 | — | — | — | 3 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | — | — | — | 1 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 1 | — | — | — | 1 |
| Interstitial lung diseases | D017563 | HP_0006530 | J84.89 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | — | — | — | — | 1 |
| Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
| Rhabdomyosarcoma | D012208 | — | — | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TALADEGIB |
| INN | taladegib |
| Description | Taladegib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein smoothened. |
| Classification | Small molecule |
| Drug class | hedgehog signaling inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C(=O)c1ccc(F)cc1C(F)(F)F)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1258861-20-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2142592 |
| ChEBI ID | — |
| PubChem CID | 49848070 |
| DrugBank | — |
| UNII ID | QY8BWX1LJ5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SMO
SMO
Organism
Homo sapiens
Gene name
SMO
Gene synonyms
SMOH
NCBI Gene ID
Protein name
protein smoothened
Protein synonyms
frizzled family member 11, Protein Gx, seven transmembrane helix receptor, smoothened homolog, smoothened, frizzled family receptor, smoothened, seven transmembrane spanning receptor
Uniprot ID
Mouse ortholog
Smo (319757)
protein smoothened (P56726)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 217 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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