Suzetrigine
Journavx (suzetrigine) is a small molecule pharmaceutical. Suzetrigine was first approved as Journavx on 2025-01-30.
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Commercial
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Trade Name
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Journavx
Drug Products
FDA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Suzetrigine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| JOURNAVX | Vertex Pharmaceuticals | N-219209 RX | 2025-01-30 | 1 products, RLD, RS |
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Agency Specific
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 10 | 1 | 1 | — | — | 12 |
| Acute pain | D059787 | — | R52 | — | 1 | 3 | — | — | 4 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | 1 | 2 | — | — | 3 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | 2 | — | — | 3 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Radiculopathy | D011843 | — | M54.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Suzetrigine |
| INN | — |
| Description | Suzetrigine, sold under the brand name Journavx, is a medication used for the management of pain. It is a non-opioid, small-molecule analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous system, avoiding the addictive potential of opioids. Suzetrigine is taken by mouth.
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| Classification | Small molecule |
| Drug class | sodium channel blockers, signal transduction modulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1c([C@@H]2[C@H](C)[C@](C)(C(F)(F)F)O[C@H]2C(=O)Nc2ccnc(C(N)=O)c2)ccc(F)c1F |
Identifiers
| PDB | — |
| CAS-ID | 2649467-58-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL5314487 |
| ChEBI ID | — |
| PubChem CID | 156445116 |
| DrugBank | DB18927 |
| UNII ID | — |
Target
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Variants
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Financial
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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