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Drug ReportsSumatriptan
Sumatriptan
Imitrex, Onzetra, Sumatriptan, Tosymra, Treximet, Zembrace (sumatriptan) is a small molecule pharmaceutical. Sumatriptan was first approved as Imitrex on 1992-12-28. It is used to treat cluster headache and migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine receptor 1B. In addition, it is known to target 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 7, and 5-hydroxytryptamine receptor 1F.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Imitrex, Imitrex statdose, Onzetra, Sumatriptan (discontinued: Alsuma, Imitrex, Imitrex statdose, Sumatriptan, Sumavel dosepro, Zecuity)
Combinations
Sumatriptan naproxen, Treximet (discontinued: Treximet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sumatriptan succinate
Tradename
Company
Number
Date
Products
ONZETRA XSAILCurrax PharmaceuticalsN-206099 RX2016-01-27
1 products, RLD, RS
IMITREXGSKN-020132 RX1995-06-01
3 products, RLD
IMITREX STATDOSEGSKN-020080 RX1996-12-23
2 products, RLD, RS
Show 4 discontinued
Sumatriptan
Tradename
Company
Number
Date
Products
IMITREXGSKN-020626 RX1997-08-26
2 products, RLD, RS
Show 1 discontinued
Naproxen sodium
+
Sumatriptan succinate
Tradename
Company
Number
Date
Products
TREXIMETCurrax PharmaceuticalsN-021926 RX2008-04-15
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
imitrexNew Drug Application2024-03-22
migraine packANDA2017-01-13
migranowunapproved drug other2024-12-13
onzetra xsailNew Drug Application2024-04-18
sumansetronunapproved drug other2023-01-11
sumatriptanANDA2025-01-13
sumatriptan and naproxen sodiumANDA2025-01-02
sumatriptan succinateANDA2024-12-11
sumatriptan succinate and naproxen sodiumNDA authorized generic2024-12-24
sumavel doseproNew Drug Application2014-02-07
Show 3 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
migraine disordersEFO_0003821D008881G43
cluster headacheHP_0012199D003027G44.00
juvenile arthritisEFO_1002007D001171M08
ankylosing spondylitisEFO_0003898D013167M45
rheumatoid arthritisEFO_0000685D001172M06.9
headacheHP_0002315D006261R51
feverHP_0001945D005334R50.9
inflammationMP_0001845D007249—
osteoarthritisEFO_0002506D010003M15-M19
bursitisEFO_1000941D002062M71.9
Show 5 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Sumatriptan Succinate, Zembrace Symtouch, Tonix Meds
105375542036-01-29U-72
113642242036-01-29U-72
Sumatriptan Succinate, Onzetra Xsail, Currax
100766142034-10-20DP
104785742033-11-04U-2404
89786472030-12-06DP
96494562030-10-21DPU-1719, U-2010, U-2011
88992292030-08-18DP
85500732029-10-22DP
100766152029-07-30U-2010, U-2011, U-2404
107226672028-12-30DP
88757042028-04-07DPU-1809
103988592027-12-19DP
101241322027-03-06DPU-1719, U-2010, U-2011
115715312026-02-23U-1809
85905302025-09-15DPU-1809
91080152025-09-15DP
79756902025-08-18DPU-1809
91199322024-04-23DP
Sumatriptan Succinate, Zecuity, Teva Branded Pharm
93271142032-10-08DPU-1328
89835942030-11-19DPU-1328
83666002029-04-21U-1327
92721372027-09-07DP
79730582027-04-12U-1328
81557372027-04-12U-1328
84708532027-04-12U-1328
85972722027-04-12DP
94275782027-04-12DPU-1328
Sumatriptan, Tosymra, Tonix Meds
92112822031-07-19DPU-1719
96102802030-06-16DPU-1719
99747702030-06-16DPU-1719
106033052030-06-16DPU-1719
113379622030-06-16DPU-1719
82687912026-05-09DP
84406312026-05-09DPU-1719
92832802026-05-09DP
Sumatriptan Succinate, Alsuma, Meridian Medcl
78112542027-08-26DPU-1083
Sumatriptan Succinate, Sumavel Dosepro, Endo Ventures Ltd
77760072026-11-22DP
79013852026-07-31DP
82874892024-12-06DP
Naproxen Sodium / Sumatriptan Succinate, Treximet, Currax
73321832025-10-02DPU-867, U-1719
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CC: Selective serotonin (5ht1) agonists
— N02CC01: Sumatriptan
HCPCS
Code
Description
J3030
Injection, sumatriptan succinate, 6 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
Clinical
Clinical Trials
132 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSumatriptan
INNsumatriptan
Description
Sumatriptan is a sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults. It has a role as a serotonergic agonist and a vasoconstrictor agent. It is a sulfonamide and a member of tryptamines. It is functionally related to a N,N-dimethyltryptamine. It is a conjugate acid of a sumatriptan(1+).
Classification
Small molecule
Drug classantimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Identifiers
PDB—
CAS-ID103628-46-2
RxCUI—
ChEMBL IDCHEMBL128
ChEBI ID10650
PubChem CID5358
DrugBankDB00669
UNII ID8R78F6L9VO (ChemIDplus, GSRS)
Target
Agency Approved
HTR1D
HTR1D
HTR1B
HTR1B
Organism
Homo sapiens
Gene name
HTR1D
Gene synonyms
HTR1DA, HTRL
NCBI Gene ID
3352
Protein name
5-hydroxytryptamine receptor 1D
Protein synonyms
5-HT-1D, 5-HT-1D-alpha, 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled, Serotonin 1D alpha receptor, Serotonin receptor 1D
Uniprot ID
P28221
Mouse ortholog
Htr1d (15552)
5-hydroxytryptamine receptor 1D (Q8BUW7)
Alternate
HTR1E
HTR1E
HTR1A
HTR1A
HTR5A
HTR5A
HTR6
HTR6
HTR7
HTR7
HTR1F
HTR1F
Organism
Homo sapiens
Gene name
HTR1E
Gene synonyms
NCBI Gene ID
3354
Protein name
5-hydroxytryptamine receptor 1E
Protein synonyms
5-HT-1E, 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled, S31, Serotonin receptor 1E
Uniprot ID
Q9P1Y1
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Tosymra – Tonix Pharmaceuticals
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Estimated US medical usage
Sumatriptan
+
Naproxen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Sumatriptan
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,371 documents
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Safety
Black-box Warning
Black-box warning for: Sumatriptan and naproxen sodium, Sumatriptan succinate and naproxen sodium, Treximet
Adverse Events
Top Adverse Reactions
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25,853 adverse events reported
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