Sulfasalazine
Azulfidine, Sulfasalazine (sulfasalazine) is a small molecule pharmaceutical. Sulfasalazine was first approved as Azulfidine on 1982-01-01. It is used to treat juvenile arthritis, rheumatoid arthritis, and ulcerative colitis in the USA. It is known to target proton-coupled folate transporter.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Azulfidine, Azulfidine en-tabs (generic drugs available since 1982-01-01, discontinued: S.a.s)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
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Indications
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Clinical
Clinical Trials
109 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 6 | 19 | 20 | 8 | 52 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | 1 | 2 | 1 | 7 | 3 | 13 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | 1 | 2 | 2 | 5 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 1 | 1 | — | 2 |
| Spondylarthritis | D025241 | — | — | — | — | — | 1 | — | 1 |
| Heart disease risk factors | D000082742 | — | — | — | — | — | 1 | — | 1 |
| Vascular stiffness | D059289 | — | — | — | — | — | 1 | — | 1 |
| Therapeutics | D013812 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | 1 | — | 2 | 3 |
| Spondylarthropathies | D025242 | EFO_0000706 | M47 | — | — | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | — | 1 | — | — | 1 |
| Oral lichen planus | D017676 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 1 | — | — | — | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | 1 | — | — | — | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Chronic pain | D059350 | HP_0012532 | — | — | 1 | — | — | — | 1 |
| Sclerosing cholangitis | D015209 | EFO_0004268 | K83.01 | — | 1 | — | — | — | 1 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Intestinal obstruction | D007415 | — | K56.60 | 2 | — | — | — | — | 2 |
| Magnetic resonance imaging | D008279 | — | — | 1 | — | — | — | — | 1 |
| Oral administration | D000284 | — | — | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Vomiting | D014839 | HP_0002013 | R11.1 | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | — | — | — | — | 2 | 2 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | — | — | 1 | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | — | — | 1 | 1 |
| Nutrition disorders | D009748 | EFO_0001069 | — | — | — | — | — | 1 | 1 |
| Dumping syndrome | D004377 | EFO_1001307 | K91.1 | — | — | — | — | 1 | 1 |
| Feeding and eating disorders | D001068 | — | F50 | — | — | — | — | 1 | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sulfasalazine |
| INN | sulfasalazine |
| Description | Sulfasalazine is an azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position. It has a role as a non-steroidal anti-inflammatory drug, an antiinfective agent, a gastrointestinal drug, an EC 2.5.1.18 (glutathione transferase) inhibitor, a drug allergen and a ferroptosis inducer. It is a sulfonamide, a member of pyridines and a member of azobenzenes. It is functionally related to a sulfanilamide. |
| Classification | Small molecule |
| Drug class | antiarrhythmic/antianginal/antihypertensive agents, phthalazine like structure; anti-inflammatory agents (salicylic acid derivatives); antimicrobials (sulfonamides derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O |
Identifiers
| PDB | — |
| CAS-ID | 599-79-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL421 |
| ChEBI ID | 9334 |
| PubChem CID | 5339 |
| DrugBank | DB00795 |
| UNII ID | 3XC8GUZ6CB (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLC46A1
SLC46A1
Organism
Homo sapiens
Gene name
SLC46A1
Gene synonyms
G21, HCP1, PCFT
NCBI Gene ID
Protein name
proton-coupled folate transporter
Protein synonyms
Heme carrier protein 1, PCFT/HCP1, solute carrier family 46 (folate transporter), member 1, Solute carrier family 46 member 1
Uniprot ID
Mouse ortholog
Slc46a1 (52466)
proton-coupled folate transporter (Q9D1P1)
Variants
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Trends
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Safety
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41,735 adverse events reported
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