Sulfasalazine
Azulfidine, Sulfasalazine (sulfasalazine) is a small molecule pharmaceutical. Sulfasalazine was first approved as Azulfidine on 1982-01-01. It is used to treat juvenile arthritis, rheumatoid arthritis, and ulcerative colitis in the USA. It is known to target proton-coupled folate transporter.
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Commercial
Trade Name
FDA
EMA
Azulfidine en-tabs, Sulfasalazine (discontinued: Azulfidine, S.a.s, Sulfasalazine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sulfasalazine
Tradename
Company
Number
Date
Products
AZULFIDINEPfizerN-007073 RX1982-01-01
1 products, RLD, RS
AZULFIDINE EN-TABSPfizerN-007073 RX1983-04-06
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
azulfidineNew Drug Application2025-01-09
sulfasalazineNDA authorized generic2025-02-27
sulfasalazine delayed-release2007-08-31
sulfazalazine2007-08-31
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
A07E: Intestinal antiinflammatory agents
A07EC: Aminosalicylic acid and similar agents
A07EC01: Sulfasalazine
HCPCS
No data
Clinical
Clinical Trials
134 clinical trials
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Indications Phases 2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients415
OsteomyelitisD010019EFO_0003102M86112
RecurrenceD012008112
Therapeutic equivalencyD01381022
Intestinal obstructionD007415K56.6022
Magnetic resonance imagingD00827911
Oral administrationD00028411
PharmacokineticsD01059911
Type 2 diabetes mellitusD003924EFO_0001360E1111
VomitingD014839R11.111
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Indications Without Phase
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSulfasalazine
INNsulfasalazine
Description
Sulfasalazine is an azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position. It has a role as a non-steroidal anti-inflammatory drug, an antiinfective agent, a gastrointestinal drug, an EC 2.5.1.18 (glutathione transferase) inhibitor, a drug allergen and a ferroptosis inducer. It is a sulfonamide, a member of pyridines and a member of azobenzenes. It is functionally related to a sulfanilamide.
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Classification
Small molecule
Drug classantiarrhythmic/antianginal/antihypertensive agents, phthalazine like structure; anti-inflammatory agents (salicylic acid derivatives); antimicrobials (sulfonamides derivatives)
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Structure (InChI/SMILES or Protein Sequence)
O=C(O)c1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O
Identifiers
PDB
CAS-ID599-79-1
RxCUI
ChEMBL IDCHEMBL421
ChEBI ID9334
PubChem CID5339
DrugBankDB00795
UNII ID3XC8GUZ6CB (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SLC46A1
SLC46A1
Organism
Homo sapiens
Gene name
SLC46A1
Gene synonyms
G21, HCP1, PCFT
NCBI Gene ID
Protein name
proton-coupled folate transporter
Protein synonyms
Heme carrier protein 1, PCFT/HCP1, solute carrier family 46 (folate transporter), member 1, Solute carrier family 46 member 1
Uniprot ID
Mouse ortholog
Slc46a1 (52466)
proton-coupled folate transporter (Q9D1P1)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 38,392 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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57,709 adverse events reported
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