Sulfadoxine
Fansidar (sulfadoxine) is a small molecule pharmaceutical. Sulfadoxine was first approved as Fansidar on 1982-01-01. It is used to treat falciparum malaria and pneumocystis pneumonia in the USA. It is known to target hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
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FDA
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Clinical
Clinical Trials
179 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | 9 | 18 | 56 | 32 | 51 | 153 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 1 | 5 | 11 | 8 | 12 | 34 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | 5 | 6 | 14 | 25 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 5 | 3 | 5 | 14 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 3 | 1 | 3 | 7 |
| Infections | D007239 | EFO_0000544 | — | 1 | — | 2 | 1 | 2 | 6 |
| Birth weight | D001724 | EFO_0004344 | — | — | — | — | 2 | 2 | 4 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | 1 | 1 | 1 | 3 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | 1 | 1 | 1 | 3 |
| Hiv | D006678 | — | O98.7 | 1 | — | — | 1 | — | 2 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vivax malaria | D016780 | EFO_0007445 | B51 | — | 1 | 2 | — | 2 | 5 |
| Parasitemia | D018512 | — | — | 1 | 1 | 1 | — | 1 | 4 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 1 | 2 | — | — | 3 |
| Sexually transmitted diseases | D012749 | — | A50-A64 | — | — | 2 | — | — | 2 |
| Only child | D009863 | — | — | — | — | 2 | — | — | 2 |
| Asymptomatic diseases | D058070 | — | — | — | — | 1 | — | — | 1 |
| Child mortality | D046688 | — | — | — | — | 1 | — | — | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Healthy volunteers/patients | — | — | — | — | — | 1 | — | — | 1 |
| Reproductive tract infections | D060737 | — | — | — | — | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schistosomiasis | D012552 | EFO_1001475 | B65 | — | 1 | — | — | 2 | 3 |
| Vaso-occlusive crises | D000098644 | — | — | 1 | 1 | — | — | — | 1 |
| Schistosomiasis haematobia | D012553 | EFO_0007530 | B65.0 | — | 1 | — | — | — | 1 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | — | — | — | — | 1 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | 1 | — | — | — | — | 1 |
| Lymphadenopathy | D000072281 | — | R59.1 | 1 | — | — | — | — | 1 |
| Splenomegaly | D013163 | — | R16.1 | 1 | — | — | — | — | 1 |
| Autoimmune lymphoproliferative syndrome | D056735 | — | D89.82 | 1 | — | — | — | — | 1 |
| Fasting | D005215 | EFO_0002756 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 6 | 6 |
| Growth disorders | D006130 | — | — | — | — | — | — | 2 | 2 |
| Severe acute malnutrition | D000067011 | — | — | — | — | — | — | 2 | 2 |
| Nutrition disorders | D009748 | EFO_0001069 | — | — | — | — | — | 1 | 1 |
| Fever | D005334 | — | R50.9 | — | — | — | — | 1 | 1 |
| Neurobehavioral manifestations | D019954 | EFO_0004364 | — | — | — | — | — | 1 | 1 |
| Behavior | D001519 | GO_0007610 | STY/T053 | — | — | — | — | 1 | 1 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Child development | D002657 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sulfadoxine |
| INN | sulfadoxine |
| Description | Sulfadoxine is a sulfonamide consisting of pyrimidine having methoxy substituents at the 5- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. In combination with the antiprotozoal pyrimethamine (CHEBI:8673) it is used as an antimalarial. It has a role as an antibacterial drug and an antimalarial. It is a sulfonamide and a member of pyrimidines. |
| Classification | Small molecule |
| Drug class | antimicrobials (sulfonamides derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC |
Identifiers
| PDB | — |
| CAS-ID | 2447-57-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1539 |
| ChEBI ID | 9329 |
| PubChem CID | 17134 |
| DrugBank | DB01299 |
| UNII ID | 88463U4SM5 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
Organism
Plasmodium falciparum 3D7
Gene name
Gene synonyms
NCBI Gene ID
Protein name
hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
Protein synonyms
Uniprot ID
Mouse ortholog
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Variants
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Trends
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Safety
Black-box Warning
No Black-box warning
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227 adverse events reported
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