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Drug ReportsSugammadex
Bridion(sugammadex)
Bridion, Sugammadex (sugammadex) is an oligosaccharide pharmaceutical. Sugammadex was first approved as Bridion on 2008-07-25. It has been approved in Europe to treat neuromuscular blockade.
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Events Timeline
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YTD
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FDA approval date
EMA approval date
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Study first post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
anesthesia and analgesiaD000760
investigative techniquesD008919
Trade Name
FDA
EMA
Bridion, Sugammadex (discontinued: Sugammadex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sugammadex sodium
Tradename
Company
Number
Date
Products
BRIDIONMerck & CoN-022225 RX2015-12-15
2 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
bridionNew Drug Application2024-10-15
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
SUGAMMADEX SODIUM, BRIDION, MSD SUB MERCK
2024-06-25NPP
2024-01-22M-291
Patent Expiration
Patent
Expires
Flag
FDA Information
Sugammadex Sodium, Bridion, Msd Sub Merck
RE447332026-01-27DS, DPU-1794
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AB: Antidotes
— V03AB35: Sugammadex
HCPCS
No data
Clinical
Clinical Trials
314 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neuromuscular blockadeD019148——1915432895
General anesthesiaD000768———8122931
Delayed emergence from anesthesiaD055191——12—91527
AnesthesiaD000758———167619
DiseaseD004194EFO_0000408R69———437
Urinary retentionD016055HP_0000016R33111316
Postoperative nausea and vomitingD020250EFO_0004888———1315
VomitingD014839HP_0002013R11.1——1315
Postoperative complicationsD011183—————325
Muscle relaxationD009126—————415
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Morbid obesityD009767EFO_0001074——31—14
Stomach neoplasmsD013274EFO_0003897C16——1—12
Prostatic neoplasmsD011471—C61——1—12
Blood pressureD001794EFO_0004325——11——1
Anesthesia and analgesiaD000760———11——1
Heart rateD006339EFO_0004326——11——1
Beta-thalassemiaD017086Orphanet_848D56.1—11——1
ThalassemiaD013789EFO_1001996D56—11——1
HepatoblastomaD018197—C22.2—11——1
BurnsD002056—T30.0——1——1
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hip osteoarthritisD015207EFO_1000786M16—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypersensitivityD006967HP_0012393T78.402————2
Kidney diseasesD007674EFO_0003086N081————1
High-frequency jet ventilationD006611——1————1
AnaphylaxisD000707—T88.61————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bariatric surgeryD050110——————33
IntubationD007440——————33
Thyroid diseasesD013959HP_0000820E00-E07————22
Critical illnessD016638——————22
Colorectal neoplasmsD015179——————22
MyalgiaD063806HP_0003326M79.1————22
Patient satisfactionD017060——————22
Neurologic manifestationsD009461——————22
Myasthenia gravisD009157EFO_0004991G70.0————22
Cardiac arrhythmiasD001145EFO_0004269I49.9————11
Show 46 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSugammadex
INNsugammadex
Description
Sugammadex is an octasaccharide derivative that is gamma-cyclodextrin in which all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. Used (as the octasodium salt) for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent. It is an octasaccharide derivative and an organic sulfide. It is functionally related to a gamma-cyclodextrin. It is a conjugate acid of a sugammadex(8-).
Classification
Oligosaccharide
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C(O)CCSC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]4[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]5[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]6[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]7[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]8[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]9[C@@H](CSCCC(=O)O)O[C@H](O[C@H]1[C@H](O)C2O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O
Identifiers
PDB—
CAS-ID343306-71-8
RxCUI—
ChEMBL IDCHEMBL2111107
ChEBI ID—
PubChem CID6918585
DrugBankDB06206
UNII ID361LPM2T56 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Bridion – Merck & Co
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,640 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,057 adverse events reported
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