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Drug ReportsSugammadex
Bridion(sugammadex)
Bridion, Sugammadex (sugammadex) is an oligosaccharide pharmaceutical. Sugammadex was first approved as Bridion on 2008-07-25. It has been approved in Europe to treat neuromuscular blockade.
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FDA approval date
EMA approval date
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Study first post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
anesthesia and analgesiaD000760
investigative techniquesD008919
Trade Name
FDA
EMA
Bridion, Sugammadex (discontinued: Sugammadex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sugammadex sodium
Tradename
Company
Number
Date
Products
BRIDIONMerck & CoN-022225 RX2015-12-15
2 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
bridionNew Drug Application2025-01-29
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
SUGAMMADEX SODIUM, BRIDION, MSD SUB MERCK
2024-06-25NPP
2024-01-22M-291
Patent Expiration
Patent
Expires
Flag
FDA Information
Sugammadex Sodium, Bridion, Msd Sub Merck
RE447332026-01-27DS, DPU-1794
ATC Codes
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AB: Antidotes
— V03AB35: Sugammadex
HCPCS
No data
Clinical
Clinical Trials
319 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Neuromuscular blockadeD019148———3816330
AnesthesiaD000758————51—6
Postoperative complicationsD011183—————3—3
Intestinal diseasesD007410—K63.9———2—2
Obstructive sleep apneaD020181EFO_0003918G47.33———2—2
Urologic neoplasmsD014571—C64-C68———2—2
NeoplasmsD009369—C80———2—2
Delayed emergence from anesthesiaD055191—————2—2
Urinary retentionD016055—R33——11—2
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
General anesthesiaD000768———612——18
Renal insufficiencyD051437—N191—2——3
Elective surgical proceduresD017558————1——1
Replacement arthroplasty kneeD019645————1——1
Replacement arthroplasty hipD019644————1——1
Hip fracturesD006620EFO_0003964S72.00——1——1
Blood coagulationD001777GO_0007596———1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypersensitivityD006967EFO_0003785T78.402————2
High-frequency jet ventilationD006611——1————1
AnaphylaxisD000707—T78.21————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Thoracic surgical proceduresD019616——————11
Pulmonary atelectasisD001261—J98.1————11
One-lung ventilationD061810——————11
Ventral herniaD006555EFO_1001866K43————11
HerniaD006547—K40-K46————11
PneumoperitoneumD011027——————11
Prostatic neoplasmsD011471—C61————11
Kidney neoplasmsD007680EFO_0003865C64————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSugammadex
INNsugammadex
Description
Sugammadex is an octasaccharide derivative that is gamma-cyclodextrin in which all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. Used (as the octasodium salt) for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent. It is an octasaccharide derivative and an organic sulfide. It is functionally related to a gamma-cyclodextrin. It is a conjugate acid of a sugammadex(8-).
Classification
Oligosaccharide
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
O=C(O)CCSC[C@H]1O[C@@H]2O[C@@H]3[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]4[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]5[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]6[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]7[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]8[C@@H](CSCCC(=O)O)O[C@H](O[C@@H]9[C@@H](CSCCC(=O)O)O[C@H](O[C@H]1[C@H](O)C2O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O
Identifiers
PDB—
CAS-ID343306-71-8
RxCUI—
ChEMBL IDCHEMBL2111107
ChEBI ID—
PubChem CID6918585
DrugBankDB06206
UNII ID361LPM2T56 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Bridion – Merck & Co
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,824 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,199 adverse events reported
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