Sucralose
Sucralose is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
166 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | 1 | 3 | 4 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | 1 | 1 | 1 | 3 |
| Esophagitis | D004941 | HP_0100633 | K20 | — | 1 | 1 | 1 | 1 | 3 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | 1 | 1 | 2 |
| Cigarette smoking | D000073865 | — | — | — | — | — | 1 | — | 1 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | — | — | 1 | — | 1 |
| Short bowel syndrome | D012778 | — | K90.82 | — | — | — | 1 | — | 1 |
| Intestinal failure | D000090124 | — | K90.83 | — | — | — | 1 | — | 1 |
| Tooth bleaching | D014073 | — | — | — | — | — | 1 | — | 1 |
| Sensitivity and specificity | D012680 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 2 | 5 | 4 | — | — | 11 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 2 | — | 8 | 10 |
| Seizures | D012640 | — | G40.4 | 2 | — | 2 | — | — | 4 |
| Myoclonic epilepsies | D004831 | EFO_1001900 | G40.4 | — | 1 | 2 | — | — | 3 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | 1 | 1 | — | 1 | 2 |
| Infantile spasms | D013036 | EFO_1000643 | G40.82 | — | — | 2 | — | — | 2 |
| Tuberous sclerosis | D014402 | — | Q85.1 | — | — | 2 | — | — | 2 |
| Lennox gastaut syndrome | D065768 | — | G40.81 | — | — | 2 | — | — | 2 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | — | 1 | 1 | — | — | 1 |
| Rett syndrome | D015518 | Orphanet_778 | F84.2 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | 2 | — | — | 11 | 17 |
| Overweight | D050177 | — | E66.3 | — | 1 | — | — | 4 | 5 |
| Body weight | D001835 | EFO_0004338 | — | — | 1 | — | — | 3 | 4 |
| Autism spectrum disorder | D000067877 | — | F84.0 | — | 2 | — | — | — | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 2 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | 1 | 2 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | 2 | — | — | — | 2 |
| Tremor | D014202 | — | R25.1 | — | 1 | — | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | — | 1 | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | — | — | — | 1 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | — | O98.7 | 1 | — | — | — | — | 1 |
| Burns | D002056 | — | T30.0 | 1 | — | — | — | — | 1 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 12 | 12 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 9 | 9 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | — | 8 | 8 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 5 | 5 |
| Appetitive behavior | D001070 | — | — | — | — | — | — | 4 | 4 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 4 | 4 |
| Weight loss | D015431 | — | — | — | — | — | — | 4 | 4 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 3 | 3 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 3 | 3 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sucralose |
| INN | _ |
| Description | Sucralose is a disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond. It has a role as an environmental contaminant, a xenobiotic and a sweetening agent. It is a disaccharide derivative and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | OC[C@@H]1O[C@H](O[C@]2(CCl)O[C@H](CCl)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H](O)[C@H]1Cl |
Identifiers
| PDB | — |
| CAS-ID | 56038-13-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2107529 |
| ChEBI ID | — |
| PubChem CID | 71485 |
| DrugBank | — |
| UNII ID | 96K6UQ3ZD4 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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34 adverse events reported
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