Sucralfate
Carafate, Sucralfate (sucralfate) is an unknown pharmaceutical. Sucralfate was first approved as Carafate on 1982-01-01. It is used to treat duodenal ulcer, esophagitis, gastritis, pneumonia, and stomach ulcer amongst others in the USA.
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Carafate (generic drugs available since 1996-03-29)
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Brand Name | Status | Last Update |
|---|---|---|
| varecell intensive liposome doublecream | unapproved drug other | 2021-09-07 |
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Clinical
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213 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | — | 1 | 1 | 2 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | 1 | — | 2 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | 1 | — | 1 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | — | — | 1 | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 1 | — | 1 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | — | — | — | 1 | — | 1 |
| Umbilical hernia | D006554 | — | K42 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | — | — | 2 | — | — | 2 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | — | 1 | — | 1 | 2 |
| Mucositis | D052016 | EFO_1001898 | — | — | — | 1 | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | 1 | — | — | 1 |
| Mediastinal neoplasms | D008479 | — | C38.3 | — | — | 1 | — | — | 1 |
| Oropharyngeal neoplasms | D009959 | — | — | — | — | 1 | — | — | 1 |
| Laryngeal neoplasms | D007822 | EFO_0003817 | C32 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | 3 | 4 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | 1 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | 1 | 2 |
| Rotator cuff tear arthropathy | D000070656 | — | — | — | 1 | — | — | — | 1 |
| Herpangina | D006557 | EFO_0007306 | B08.5 | — | 1 | — | — | — | 1 |
| Foot and mouth disease hand | D006232 | EFO_0007294 | B08.4 | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | — | 1 | — | — | — | 1 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | 1 | — | — | — | — | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 7 | 7 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 6 | 6 |
| Rotator cuff injuries | D000070636 | — | M75.1 | — | — | — | — | 5 | 5 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | — | — | 5 | 5 |
| Pelvic pain | D017699 | — | — | — | — | — | — | 4 | 4 |
| Shoulder pain | D020069 | HP_0030834 | M25.51 | — | — | — | — | 4 | 4 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | — | — | — | 4 | 4 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 3 | 3 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 3 | 3 |
| Neck pain | D019547 | HP_0030833 | M54.2 | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sucralfate |
| INN | sucralfate |
| Description | Sucralfate, sold under various brand names, is a medication used to treat stomach ulcers, gastroesophageal reflux disease (GERD), radiation proctitis, and stomach inflammation and to prevent stress ulcers. Its usefulness in people infected by H. pylori is limited. It is used by mouth (for upper GIT ulcers) and rectally (for radiation proctitis).
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O=S(=O)(OC[C@H]1O[C@@H](O[C@]2(COS(=O)(=O)O[Al](O)O)O[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]2OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]1OS(=O)(=O)O[Al](O)O)O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O.O[Al](O)O |
Identifiers
| PDB | — |
| CAS-ID | 54182-58-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989780 |
| ChEBI ID | — |
| PubChem CID | 6398525 |
| DrugBank | DB00364 |
| UNII ID | XX73205DH5 (ChemIDplus, GSRS) |
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Carafate – Allergan
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Carafate – Warner Chilcott
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Estimated US medical usage
Sucralfate
Total medical expenditures per year (USD, in millions)
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Safety
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1,700 adverse events reported
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