Succimer
Chemet (succimer) is a small molecule pharmaceutical. Succimer was first approved as Chemet on 1991-01-30. It is used to treat nervous system lead poisoning childhood in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| chemically-induced disorders | D064419 |
Trade Name
FDA
EMA
Chemet
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chemet | New Drug Application | 2024-09-24 |
| dimercaptosuccinic acid | unapproved drug other | 2012-07-01 |
| dmsa | 2007-08-03 | |
| nephroscan | New Drug Application | 2024-09-29 |
| rotop - dmsa | unapproved drug for use in drug shortage | 2021-03-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| nervous system lead poisoning childhood | — | D020264 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09C: Renal system diagnostic radiopharmaceuticals
— V09CA: Technetium (99mtc) compounds
— V09CA02: Technetium (99mtc) succimer
— V09I: Tumour detection radiopharmaceuticals
— V09IA: Technetium (99mtc) compounds
— V09IA03: Technetium (99mtc) pentavalent succimer
HCPCS
Code | Description |
|---|---|
| A9551 | Technetium tc-99m succimer, diagnostic, per study dose, up to 10 millicuries |
Clinical
Clinical Trials
43 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pyelonephritis | D011704 | EFO_1001141 | N10-N16 | — | — | 1 | 3 | 2 | 6 |
| Vesico-ureteral reflux | D014718 | EFO_0007536 | N13.7 | — | — | 1 | 1 | 1 | 3 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | 2 | — | 2 |
| Psychotic disorders | D011618 | — | F20.81 | — | — | — | 2 | — | 2 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 1 | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | 1 | — | 1 |
| Psychotic affective disorders | D000341 | — | F39 | — | — | — | 1 | — | 1 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | — | — | 1 | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | 1 | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | 1 | — | 1 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lead poisoning | D007855 | — | T56.0 | — | — | 1 | — | 2 | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autistic disorder | D001321 | HP_0000717 | F84.0 | 1 | 2 | — | — | — | 2 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | 1 | — | — | 1 | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | — | 1 |
| Heavy metal poisoning | D000075322 | — | T56 | 1 | 1 | — | — | — | 1 |
| Developmental disabilities | D002658 | EFO_0003852 | F89 | — | 1 | — | — | — | 1 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | — | 1 | — | — | — | 1 |
| Asperger syndrome | D020817 | EFO_0003757 | F84.5 | — | 1 | — | — | — | 1 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | — | 1 | — | — | — | 1 |
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | — | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatolenticular degeneration | D006527 | Orphanet_905 | E83.01 | 1 | — | — | — | 1 | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | — | — | — | — | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
Show 11 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 2 | 2 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | — | — | — | — | 2 | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 2 | 2 |
| Glioma | D005910 | EFO_0000520 | — | — | — | — | — | 2 | 2 |
| Radiation | D011827 | — | — | — | — | — | — | 1 | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Urologic diseases | D014570 | — | N39.9 | — | — | — | — | 1 | 1 |
Show 7 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Succimer |
| INN | succimer |
| Description | Succimer is a sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning. It has a role as a chelator. It is a dicarboxylic acid, a dithiol and a sulfur-containing carboxylic acid. |
| Classification | Small molecule |
| Drug class | polymers |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)[C@H](S)[C@H](S)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 304-55-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201073 |
| ChEBI ID | 63623 |
| PubChem CID | 2724354 |
| DrugBank | DB00566 |
| UNII ID | DX1U2629QE (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
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Estimated US medical usage
Succimer
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,349 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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56 adverse events reported
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