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Drug ReportsStrontium
Strontium ranelate
Osseor, Protelos (strontium ranelate) is a small molecule pharmaceutical. Strontium ranelate was first approved as Protelos on 2004-09-20. It has been approved in Europe to treat postmenopausal osteoporosis.
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Events Timeline
5D
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
M: Musculo-skeletal system drugs
— M05: Drugs for treatment of bone diseases
— M05B: Drugs affecting bone structure and mineralization
— M05BX: Other drugs affecting bone structure and mineralization in atc
— M05BX03: Strontium ranelate
— M05BX53: Strontium ranelate and colecalciferol
HCPCS
No data
Clinical
Clinical Trials
43 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.011—428
Bone fracturesD050723EFO_0003931T14.8———123
Metabolic bone diseasesD001851——1——113
Postmenopausal osteoporosisD015663EFO_0003854————213
HyperparathyroidismD006961EFO_0008506E21.3———1—1
Primary hyperparathyroidismD049950EFO_0008519E21.0———1—1
ComplianceD003187—————1—1
Coronary diseaseD003327—————1—1
Coronary artery diseaseD003324—I25.1———1—1
Myocardial ischemiaD017202EFO_1001375I20-I25———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471—C61—43——7
HypersensitivityD006967EFO_0003785T78.40—12—57
Dentin sensitivityD003807———12—57
NeoplasmsD009369—C80—32——5
PainD010146EFO_0003843R52122——5
Breast neoplasmsD001943EFO_0003869C50——1—12
Knee osteoarthritisD020370EFO_0004616M17——1—12
OsteoarthritisD010003EFO_0002506M15-M19——1—12
Lung neoplasmsD008175—C34.90——1——1
Neoplasm metastasisD009362EFO_0009708———1——1
Indications Phases 2
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Ontology
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PruritusD011537—L29—1———1
Indications Phases 1
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Ontology
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ErythemaD004890—L53.91————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dental cariesD003731EFO_0003819K02————33
Radiation exposureD000069079——————22
InfertilityD007246EFO_0000545—————22
Macular degenerationD008268EFO_0001365H35.30————11
Choroidal neovascularizationD020256——————11
Pathologic neovascularizationD009389——————11
Calcium metabolism disordersD002128EFO_0005769E83.5————11
Premature birthD047928EFO_0003917O60————11
Primary ovarian insufficiencyD016649EFO_0004266E28.3————11
Premature menopauseD008594—E28.31————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameStrontium ranelate
INN—
Description
Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA).
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
N#Cc1c(N(CC(=O)[O-])CC(=O)[O-])sc(C(=O)[O-])c1CC(=O)[O-].[Sr+2].[Sr+2]
Identifiers
PDB—
CAS-ID135459-87-9
RxCUI—
ChEMBL IDCHEMBL3707306
ChEBI ID—
PubChem CID6918182
DrugBank—
UNII ID—
Target
No data
Variants
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Financial
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Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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205 adverse events reported
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