Strontium ranelate
Osseor, Protelos (strontium ranelate) is a small molecule pharmaceutical. Strontium ranelate was first approved as Protelos on 2004-09-20. It has been approved in Europe to treat postmenopausal osteoporosis.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| musculoskeletal diseases | D009140 |
| nutritional and metabolic diseases | D009750 |
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8 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | 1 | — | 4 | 1 | 6 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | 1 | 1 | 2 |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | — | — | — | 2 | — | 2 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | — | — | — | 1 | — | 1 |
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | — | — | — | 1 | — | 1 |
| Primary hyperparathyroidism | D049950 | EFO_0008519 | E21.0 | — | — | — | 1 | — | 1 |
| Compliance | D003187 | — | — | — | — | — | 1 | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Strontium ranelate |
| INN | — |
| Description | Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA).
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#Cc1c(N(CC(=O)[O-])CC(=O)[O-])sc(C(=O)[O-])c1CC(=O)[O-].[Sr+2].[Sr+2] |
Identifiers
| PDB | — |
| CAS-ID | 135459-87-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707306 |
| ChEBI ID | — |
| PubChem CID | 6918182 |
| DrugBank | — |
| UNII ID | — |
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221 adverse events reported
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