Streptozocin
Zanosar (streptozocin) is a small molecule pharmaceutical. Streptozocin was first approved as Zanosar on 1982-05-07. It is used to treat colorectal neoplasms, hodgkin disease, and islet cell carcinoma in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Zanosar
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| zanosar | New Drug Application | 2023-04-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| colorectal neoplasms | — | D015179 | — |
| hodgkin disease | — | D006689 | C81 |
| islet cell carcinoma | — | D018273 | C25.4 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J9320 | Injection, streptozocin, 1 gram |
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 1 | 1 | — | 1 | 3 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | 1 | — | — | 2 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | 1 | — | — | 1 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | 1 | — | — | 1 |
| Adrenocortical carcinoma | D018268 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
| Endocrine gland neoplasms | D004701 | EFO_0003769 | D35 | — | 2 | — | — | — | 2 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | — | 2 | — | — | — | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 1 | — | — | — | 1 |
| Carcinoid tumor | D002276 | — | D3A.00 | — | 1 | — | — | — | 1 |
| Malignant carcinoid syndrome | D008303 | — | E34.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Streptozocin |
| INN | streptozocin |
| Description | Streptozocin is an N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. It has a role as an antineoplastic agent, an antimicrobial agent, a DNA synthesis inhibitor and a metabolite. It is a N-acylglucosamine and a member of N-nitrosoureas. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(N=O)C(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 18883-66-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1651906 |
| ChEBI ID | — |
| PubChem CID | 29327 |
| DrugBank | DB00428 |
| UNII ID | 5W494URQ81 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Zanosar
Adverse Events
Top Adverse Reactions
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195 adverse events reported
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