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AboutPricing
Drug ReportsStavudine
Zerit(stavudine)
Zerit (stavudine) is a small molecule pharmaceutical. Stavudine was first approved as Zerit on 1994-06-24. It is used to treat acquired immunodeficiency syndrome and HIV infections in the USA. It has been approved in Europe to treat HIV infections.
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Events Timeline
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YTD
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2Y
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FDA approval date
EMA approval date
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Study first post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Stavudine
Tradename
Company
Number
Date
Products
ZERITBristol Myers SquibbN-020412 DISCN1994-06-24
5 products, RLD
ZERITBristol Myers SquibbN-020413 DISCN1996-09-06
1 products, RLD
ZERIT XRBristol Myers SquibbN-021453 DISCN2002-12-31
4 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acquired immunodeficiency syndromeEFO_0000765D000163B20
hiv infectionsEFO_0000764D015658B20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AF: Nucleoside and nucleotide reverse transcriptase inhibitors
— J05AF04: Stavudine
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR07: Stavudine, lamivudine and nevirapine
HCPCS
No data
Clinical
Clinical Trials
172 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B201652362132152
Acquired immunodeficiency syndromeD000163EFO_0000765B20—266113
HivD006678—O98.71226212
TuberculosisD014376EFO_0000774A15-A191321—6
LipodystrophyD008060HP_0009125E88.1—2—3—5
Cryptococcal meningitisD016919EFO_0007228B45.1———112
Lactic acidosisD000140HP_0003128E87.20—111—2
Hiv-1D015497—————1—1
HepatitisD006505HP_0012115K75.9———1—1
ExanthemaD005076HP_0000988————1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B54——1——1
Aids-associated nephropathyD016263EFO_0007313———1——1
DiarrheaD003967HP_0002014R19.7——1——1
Aids dementia complexD015526EFO_0002608———1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv seropositivityD006679———1———1
Metabolic diseasesD008659EFO_0000589E88.9—1———1
Metabolic syndromeD024821EFO_0000195E88.810—1———1
Nutrition disordersD009748EFO_0001069——1———1
Insulin resistanceD007333HP_0000855E88.819—1———1
HyperlactatemiaD065906———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.11————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis cD006526—B19.2————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameStavudine
INNstavudine
Description
Stavudine is a nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase It has a role as an antimetabolite, an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor and an antiviral agent. It is an organic molecular entity, a nucleoside analogue and a dihydrofuran. It is functionally related to a thymine.
Classification
Small molecule
Drug classantineoplastics; antivirals (zidovudine group) (exception: edoxudine)
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Structure (InChI/SMILES or Protein Sequence)
Cc1cn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]c1=O
Identifiers
PDB—
CAS-ID3056-17-5
RxCUI—
ChEMBL IDCHEMBL991
ChEBI ID63581
PubChem CID18283
DrugBankDB00649
UNII IDBO9LE4QFZF (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Stavudine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,751 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,447 adverse events reported
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