Spartalizumab
Spartalizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against programmed cell death protein 1.
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Commercial
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Clinical
Clinical Trials
67 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 6 | 5 | 1 | — | — | 10 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 4 | 1 | — | — | 7 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 14 | 6 | — | — | — | 15 |
| Non-small-cell lung carcinoma | D002289 | — | — | 10 | 5 | — | — | — | 14 |
| Triple negative breast neoplasms | D064726 | — | — | 9 | 5 | — | — | — | 12 |
| Colorectal neoplasms | D015179 | — | — | 7 | 2 | — | — | — | 9 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 3 | 2 | — | — | — | 5 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | 2 | — | — | — | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 3 | 1 | — | — | — | 4 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 2 | — | — | — | 3 |
| Adenocarcinoma | D000230 | — | — | — | 3 | — | — | — | 3 |
| Squamous cell neoplasms | D018307 | — | — | 1 | 2 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | — | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Bone marrow diseases | D001855 | — | — | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Spartalizumab |
| INN | spartalizumab |
| Description | Spartalizumab (INN; development code PDR001) is a monoclonal antibody and checkpoint inhibitor that is being investigated for melanoma.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297831 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | QOG25L6Z8Z (ChemIDplus, GSRS) |
Target
Agency Approved
PDCD1
PDCD1
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Safety
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247 adverse events reported
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