Sotatercept
Sotatercept is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target inhibin beta A chain.
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Commercial
No data
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary arterial hypertension | D000081029 | — | — | — | 3 | 5 | — | — | 8 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | — | 6 | — | — | — | 6 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 2 | — | — | — | 3 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Diamond-blackfan anemia | D029503 | EFO_0004130 | D61.01 | 1 | 1 | — | — | — | 1 |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | 1 | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | — | 1 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | — | 1 | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sotatercept |
| INN | sotatercept |
| Description | Sotatercept (immunoadhesin) |
| Classification | Protein |
| Drug class | receptor molecules or membrane ligands, natural, modified or modified: transforming growth factor receptors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1001080-50-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743073 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12118 |
| UNII ID | 0QI90BTJ37 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
INHBA
INHBA
Organism
Homo sapiens
Gene name
INHBA
Gene synonyms
NCBI Gene ID
Protein name
inhibin beta A chain
Protein synonyms
Activin beta-A chain, EDF, erythroid differentiation factor, Erythroid differentiation protein, follicle-stimulating hormone-releasing protein, FSH-releasing protein, inhibin beta A subunit, inhibin, beta A (activin A, activin AB alpha polypeptide), Inhibin, beta-1
Uniprot ID
Mouse ortholog
Inhba (16323)
inhibin beta A chain (Q04998)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 475 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13 adverse events reported
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