Somatostatin
Somatostatin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
350 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 35 | 55 | 20 | 2 | 32 | 126 |
| Acromegaly | D000172 | — | — | 2 | 7 | 10 | 7 | 20 | 46 |
| Neoplasms | D009369 | — | C80 | 11 | 16 | 1 | 1 | 8 | 34 |
| Paraganglioma | D010235 | — | — | 5 | 9 | — | 1 | 2 | 13 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 1 | 1 | 4 | 7 | 13 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 4 | 8 | — | 1 | 2 | 12 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | 1 | 9 | 11 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | 2 | 1 | 2 | 1 | 5 | 10 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | 1 | 1 | 1 | 1 | 7 | 10 |
| Medulloblastoma | D008527 | — | — | 2 | 7 | — | 1 | — | 8 |
Show 21 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoid tumor | D002276 | — | D3A.00 | 10 | 13 | 6 | — | 3 | 29 |
| Carcinoma | D002277 | — | C80.0 | 3 | 5 | 3 | — | 1 | 9 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | 5 | 1 | 2 | — | 1 | 9 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 4 | 1 | — | 1 | 8 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 5 | 1 | — | 2 | 8 |
| Malignant carcinoid syndrome | D008303 | — | E34.0 | 3 | 2 | 3 | — | — | 8 |
| Lung neoplasms | D008175 | — | C34.90 | 4 | 4 | 1 | — | — | 8 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 3 | 4 | — | 1 | 7 |
| Serotonin syndrome | D020230 | EFO_1001842 | G90.81 | — | 2 | 4 | — | 1 | 7 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 3 | 5 | — | 1 | 7 |
Show 28 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine carcinoma | D018278 | — | — | 4 | 9 | — | — | 6 | 16 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 4 | 7 | — | — | 2 | 11 |
| Pheochromocytoma | D010673 | — | — | 6 | 7 | — | — | 1 | 11 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 3 | — | — | 6 | 10 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 4 | 2 | — | — | 3 | 8 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 3 | 3 | — | — | 1 | 7 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 1 | — | — | 3 | 6 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | — | — | 4 | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 1 | — | — | 2 | 5 |
| Prostatic neoplasms | D011471 | — | C61 | 3 | 2 | — | — | 1 | 5 |
Show 57 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypoglycemia | D007003 | — | E16.2 | 2 | — | — | — | 5 | 7 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | 4 | 5 |
| Nervous system neoplasms | D009423 | — | — | 3 | — | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | 1 | 3 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | 1 | — | — | — | 2 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 2 | 3 |
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Paraneoplastic syndromes | D010257 | — | — | 2 | — | — | — | — | 2 |
| Glucose metabolism disorders | D044882 | — | — | 1 | — | — | — | 1 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 1 | 2 |
Show 19 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | — | — | — | 4 | 4 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 4 | 4 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | — | — | 4 | 4 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | — | — | 3 | 3 |
| Weight loss | D015431 | — | — | — | — | — | — | 3 | 3 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | — | 2 | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 2 | 2 |
| Duodenal neoplasms | D004379 | — | — | — | — | — | — | 2 | 2 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | — | — | — | 2 | 2 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 2 | 2 |
Show 61 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Somatostatin |
| INN | somatostatin |
| Description | SOMATOSTATIN |
| Classification | Protein |
| Drug class | growth hormone derivatives; enzyme inhibitors: antihyperlipidemics (HMG-CoA inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 38916-34-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1823872 |
| ChEBI ID | 64628 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6E20216Q0L (ChemIDplus, GSRS) |
Target
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Financial
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Trends
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Safety
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Adverse Events
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108 adverse events reported
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