Somatostatin
Somatostatin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
311 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 24 | 39 | 14 | 3 | 21 | 89 |
| Acromegaly | D000172 | — | — | 2 | 7 | 10 | 9 | 17 | 44 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | 2 | 1 | 2 | 1 | 5 | 10 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | 1 | 6 | 8 |
| Medulloblastoma | D008527 | — | — | 2 | 6 | — | 1 | — | 7 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 2 | 4 | — | 1 | 1 | 7 |
| Paraganglioma | D010235 | — | — | 2 | 5 | — | 1 | 1 | 7 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | 1 | 1 | 1 | 1 | 3 | 6 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | — | 1 | 1 | 5 |
| Pituitary neoplasms | D010911 | — | — | — | 3 | 1 | 2 | — | 5 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoid tumor | D002276 | — | D3A.00 | 4 | 11 | 2 | — | 1 | 16 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 3 | 6 | — | — | 7 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 2 | 4 | — | 1 | 6 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 2 | 1 | — | — | 3 |
| Glioma | D005910 | EFO_0000520 | — | 1 | 2 | 1 | — | — | 2 |
| Carcinoid heart disease | D002275 | EFO_1001769 | — | — | 1 | 1 | — | — | 2 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 1 | 1 | — | — | 2 |
| Gastrointestinal hemorrhage | D006471 | HP_0002239 | K92.2 | — | 1 | 1 | — | — | 2 |
| Thymus neoplasms | D013953 | — | C37 | — | 1 | 1 | — | — | 2 |
| Pancreatic diseases | D010182 | — | K86.9 | — | 1 | 1 | — | 1 | 2 |
Show 13 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine carcinoma | D018278 | — | — | 3 | 9 | — | — | 3 | 13 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 4 | 6 | — | — | — | 8 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 2 | — | — | 5 | 8 |
| Pheochromocytoma | D010673 | — | — | 3 | 4 | — | — | — | 6 |
| Central nervous system neoplasms | D016543 | — | — | 4 | 1 | — | — | — | 4 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 1 | — | — | — | 4 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | 1 | — | — | 2 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | — | — | — | 3 |
| Small cell lung carcinoma | D055752 | — | — | 2 | 3 | — | — | — | 3 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 2 | — | — | 1 | 3 |
Show 30 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | 1 | — | — | — | 4 | 5 |
| Insulin resistance | D007333 | HP_0000855 | E88.819 | 1 | — | — | — | 3 | 4 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | 3 | — | — | — | — | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | — | — | — | 1 | 3 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| Paraneoplastic syndromes | D010257 | — | — | 2 | — | — | — | — | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 1 | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
Show 10 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 4 | 4 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | — | — | 4 | 4 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 2 | 2 |
| Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 2 | 2 |
| Duodenal neoplasms | D004379 | — | — | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | — | — | — | 2 | 2 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | — | — | — | 2 | 2 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
| Arm injuries | D001134 | — | — | — | — | — | — | 1 | 1 |
Show 48 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Somatostatin |
| INN | somatostatin |
| Description | SOMATOSTATIN |
| Classification | Protein |
| Drug class | growth hormone derivatives; enzyme inhibitors: antihyperlipidemics (HMG-CoA inhibitors) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 38916-34-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1823872 |
| ChEBI ID | 64628 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6E20216Q0L (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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Adverse Events
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75 adverse events reported
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