Tradename | Company | Number | Date | Products |
---|---|---|---|---|
EPCLUSA | Gilead Sciences | N-208341 RX | 2016-06-28 | 2 products, RLD, RS |
EPCLUSA | Gilead Sciences | N-214187 RX | 2021-06-10 | 2 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
HARVONI | Gilead Sciences | N-205834 RX | 2014-10-10 | 2 products, RLD, RS |
HARVONI | Gilead Sciences | N-212477 RX | 2019-08-28 | 2 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
SOVALDI | Gilead Sciences | N-204671 RX | 2013-12-06 | 2 products, RLD, RS |
SOVALDI | Gilead Sciences | N-212480 RX | 2019-08-28 | 2 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
VOSEVI | Gilead Sciences | N-209195 RX | 2017-07-18 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
OTC monograph not final | 2012-09-10 | |
2 in 1laxative stool softener and stiulant laxative | OTC monograph not final | 2022-01-03 |
3 concept eyes glossing waterful foundation soft beige | OTC monograph not final | 2013-10-03 |
3 concept eyes slim fit pact soft beige | OTC monograph not final | 2013-10-03 |
30 soft wipes | OTC monograph not final | 2022-12-08 |
60 soft wipes | OTC monograph not final | 2022-12-10 |
acacia pollen american beech american elm american sycamore arizona ash arizona cypress ash mixture aspen pollen australian pine austrian pine bald... | Biologic Licensing Application, Bulk ingredient | 2009-11-19 |
accentrate pnv | unapproved drug other | 2025-03-10 |
alabaster beige expert finish makeup broad spectrum spf 25 bare expert finish makeup broad spectrum spf 25 creamy beige expert finish makeup broa... | OTC monograph final | 2021-05-20 |
alabaster beige expert finish makeup broad spectrum spf 25 bare expert finish makeup broad spectrum spf 25 creamy beige expert finish makeup broad ... | C200263 | 2024-10-07 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
hepatitis c | — | D006526 | B19.2 |
chronic hepatitis c | EFO_0004220 | D019698 | B18.2 |
Expiration | Code | ||
---|---|---|---|
SOFOSBUVIR / VELPATASVIR, EPCLUSA, GILEAD SCIENCES INC | |||
2028-12-10 | PED | ||
2028-06-10 | ODE-376 | ||
2027-09-19 | PED | ||
2027-03-19 | ODE-293 | ||
2025-04-27 | M-277 | ||
2024-01-14 | PED | ||
2023-09-19 | PED | ||
2023-07-14 | M-264 | ||
2023-05-15 | PED | ||
2023-03-19 | NPP, NS | ||
LEDIPASVIR / SOFOSBUVIR, HARVONI, GILEAD SCIENCES INC | |||
2026-08-28 | ODE*, ODE-262, ODE-263, ODE-264 | ||
2024-10-07 | PED | ||
2024-04-07 | ODE*, ODE-136 | ||
SOFOSBUVIR, SOVALDI, GILEAD SCIENCES INC | |||
2026-08-28 | ODE*, ODE-258 | ||
2024-10-07 | PED | ||
2024-04-07 | ODE*, ODE-135 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Sofosbuvir / Velpatasvir / Voxilaprevir, Vosevi, Gilead Sciences Inc | |||
10912814 | 2037-06-01 | DP | |
11338007 | 2037-06-01 | DP | U-2039, U-2040 |
9296782 | 2034-07-17 | DS, DP | |
9868745 | 2032-11-16 | DS, DP | |
8957046 | 2028-03-21 | U-2039, U-2040 | |
Sofosbuvir / Velpatasvir, Epclusa, Gilead Sciences Inc | |||
9757406 | 2034-01-30 | DP | |
10086011 | 2034-01-30 | U-1470 | |
11116783 | 2034-01-30 | DP | U-1470, U-2039, U-2040 |
11707479 | 2034-01-30 | DP | U-1470 |
8575135 | 2032-11-16 | DS, DP | U-1470, U-2039, U-2040 |
8921341 | 2032-11-16 | DS, DP | U-1470, U-2039, U-2040 |
8940718 | 2032-11-16 | DS, DP | U-1470, U-2039, U-2040 |
Ledipasvir / Sofosbuvir, Harvoni, Gilead Sciences Inc | |||
10039779 | 2034-01-30 | DS, DP | U-1470, U-2369, U-2370 |
9393256 | 2032-09-14 | U-1470 | |
10456414 | 2032-09-14 | DP | |
8618076 | 2030-12-11 | DS, DP | U-1470, U-2039, U-2040 |
9284342 | 2030-09-13 | DS, DP | U-1470, U-2039, U-2040 |
8088368 | 2030-05-12 | DS, DP | |
8273341 | 2030-05-12 | U-1470 | |
8822430 | 2030-05-12 | DS, DP | U-1470 |
8841278 | 2030-05-12 | DP | U-1470 |
9511056 | 2030-05-12 | DP | U-1470 |
7964580 | 2029-03-26 | DS, DP | U-1470, U-2039, U-2040 |
8633309 | 2029-03-26 | DS, DP | U-1470, U-2039, U-2040 |
8889159 | 2029-03-26 | DP | U-1470, U-2039, U-2040 |
8334270 | 2028-03-21 | DS, DP | U-1470, U-2039, U-2040 |
8580765 | 2028-03-21 | DS, DP | U-1470, U-2039, U-2040 |
8735372 | 2028-03-21 | U-1470, U-2039, U-2040 | |
9085573 | 2028-03-21 | DS, DP | U-1470, U-2039, U-2040 |
Sofosbuvir, Sovaldi, Gilead Sciences Inc | |||
9549941 | 2029-03-26 | U-1958 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hepatitis c | D006526 | — | B19.2 | 21 | 98 | 83 | 64 | 77 | 324 |
Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 9 | 41 | 39 | 26 | 35 | 139 |
Hepatitis | D006505 | — | K75.9 | 15 | 43 | 33 | 18 | 40 | 138 |
Hepatitis a | D006506 | EFO_0007305 | B15 | 10 | 21 | 15 | 15 | 32 | 88 |
Hepatitis b | D006509 | — | — | 2 | 24 | 29 | 4 | 7 | 64 |
Chronic hepatitis | D006521 | — | K73.9 | 1 | 8 | 6 | 1 | 9 | 22 |
Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 5 | 4 | 6 | 6 | 21 |
Fibrosis | D005355 | — | — | — | 2 | 9 | 4 | 6 | 21 |
Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 3 | 4 | 4 | 9 | 19 |
Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 2 | 12 | 6 | 3 | 1 | 19 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Infections | D007239 | EFO_0000544 | — | 1 | 22 | 19 | — | 4 | 46 |
Communicable diseases | D003141 | — | — | 1 | 20 | 14 | — | 2 | 37 |
Hepacivirus | D016174 | — | — | — | 3 | 5 | — | 5 | 13 |
Rna virus infections | D012327 | — | — | — | 2 | 1 | — | 2 | 5 |
Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | 2 | 1 | — | 2 | 5 |
Viral hepatitis human | D006525 | EFO_0004196 | — | — | 2 | 1 | — | 2 | 5 |
Flaviviridae infections | D018178 | EFO_0007274 | — | — | 2 | 1 | — | 1 | 4 |
Picornaviridae infections | D010850 | EFO_0007438 | — | — | 1 | 1 | — | 1 | 3 |
Enterovirus infections | D004769 | EFO_0007255 | B34.1 | — | 1 | 1 | — | 1 | 3 |
Kidney transplantation | D016030 | — | — | 1 | 2 | 1 | — | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | 2 | 3 |
Lymphoma | D008223 | — | C85.9 | — | 2 | — | — | — | 2 |
Gastrointestinal diseases | D005767 | — | — | — | 1 | — | — | 1 | 2 |
Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | 1 | 2 |
Hemophilia a | D006467 | EFO_0007267 | D66 | — | 1 | — | — | — | 1 |
Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | 1 | — | — | — | 1 |
Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | 1 | — | — | — | 1 |
Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | 1 | — | — | — | 1 |
Hematologic neoplasms | D019337 | — | — | 1 | 1 | — | — | — | 1 |
Hepatitis e | D016751 | EFO_0007303 | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 7 | — | — | — | 2 | 9 |
Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 4 | 5 |
Deglutition disorders | D003680 | — | R13.1 | 1 | — | — | — | — | 1 |
Camurati-engelmann syndrome | D003966 | Orphanet_1328 | Q78.3 | 1 | — | — | — | — | 1 |
Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | — | — | — | 1 |
Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | — | 1 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 2 | 2 |
Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
Hemoglobinopathies | D006453 | — | D58.2 | — | — | — | — | 1 | 1 |
Retinal diseases | D012164 | — | H35.9 | — | — | — | — | 1 | 1 |
Joint diseases | D007592 | — | M12.9 | — | — | — | — | 1 | 1 |
Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
Pregnancy complications | D011248 | — | — | — | — | — | — | 1 | 1 |
Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
Patient compliance | D010349 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Sofosbuvir |
INN | sofosbuvir |
Description | Sofosbuvir is a nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection. It has a role as a prodrug, an antiviral drug and a hepatitis C protease inhibitor. It is a L-alanyl ester, a phosphoramidate ester, a nucleotide conjugate, an organofluorine compound and an isopropyl ester. It is functionally related to a uridine 5'-monophosphate. |
Classification | Small molecule |
Drug class | phosphoro-derivatives; antivirals: RNA polymerase (NS5B) inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1 |
PDB | — |
CAS-ID | 1190307-88-0 |
RxCUI | — |
ChEMBL ID | CHEMBL1259059 |
ChEBI ID | 85083 |
PubChem CID | 45375808 |
DrugBank | DB08934 |
UNII ID | WJ6CA3ZU8B (ChemIDplus, GSRS) |