Sintilimab
Sintilimab is an antibody pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
633 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 13 | 48 | 15 | 1 | 8 | 81 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 11 | 58 | 7 | 1 | 5 | 71 |
| Lung neoplasms | D008175 | — | C34.90 | 9 | 38 | 7 | 1 | 7 | 58 |
| Adenocarcinoma | D000230 | — | — | 4 | 27 | 4 | 1 | 2 | 34 |
| Lymphoma | D008223 | — | C85.9 | 1 | 18 | 1 | 1 | — | 21 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 5 | 1 | 1 | 1 | 8 |
| Hodgkin disease | D006689 | — | C81 | — | 3 | 1 | 1 | 1 | 6 |
| Triple negative breast neoplasms | D064726 | — | — | — | 3 | — | 1 | — | 4 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | — | 1 | — | 1 | — | 2 |
| Thyroid diseases | D013959 | — | E00-E07 | — | 1 | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 7 | 70 | 15 | — | 32 | 118 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 11 | 51 | 10 | — | 39 | 103 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 9 | 46 | 9 | — | 27 | 84 |
| Neoplasms | D009369 | — | C80 | 25 | 30 | 3 | — | 5 | 53 |
| Colorectal neoplasms | D015179 | — | — | 6 | 33 | 6 | — | 9 | 50 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 25 | 8 | — | 5 | 38 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 2 | 21 | 8 | — | 5 | 35 |
| Immunotherapy | D007167 | — | — | 4 | 20 | 1 | — | 7 | 29 |
| Esophageal neoplasms | D004938 | — | C15 | 5 | 14 | 2 | — | 1 | 19 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 16 | 1 | — | — | 18 |
Show 20 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 13 | — | — | — | 13 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 2 | 11 | — | — | 2 | 13 |
| T-cell lymphoma peripheral | D016411 | — | — | 1 | 10 | — | — | — | 11 |
| T-cell lymphoma | D016399 | — | — | 1 | 10 | — | — | — | 11 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 9 | — | — | 2 | 11 |
| Drug therapy | D004358 | — | — | 1 | 5 | — | — | 2 | 8 |
| Uterine cervical neoplasms | D002583 | — | — | 1 | 7 | — | — | 1 | 8 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 1 | 6 | — | — | 1 | 7 |
| Healthy volunteers/patients | — | — | — | 4 | 4 | — | — | — | 6 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 5 | — | — | — | 6 |
Show 57 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteosarcoma | D012516 | — | — | 1 | — | — | — | — | 1 |
| Adenocarcinoma of lung | D000077192 | — | — | 1 | — | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
| Meningeal carcinomatosis | D055756 | EFO_1001012 | — | 1 | — | — | — | — | 1 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | — | 2 | 2 |
| Hepatitis b | D006509 | — | — | — | — | — | — | 2 | 2 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | — | — | — | 2 | 2 |
| Hepatitis | D006505 | — | K75.9 | — | — | — | — | 2 | 2 |
| Chronic hepatitis | D006521 | — | K73.9 | — | — | — | — | 2 | 2 |
| Catheter ablation | D017115 | — | — | — | — | — | — | 2 | 2 |
| Female genital neoplasms | D005833 | — | — | — | — | — | — | 1 | 1 |
| Abdominal neoplasms | D000008 | — | — | — | — | — | — | 1 | 1 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | — | — | — | — | 1 | 1 |
| Venous thrombosis | D020246 | — | I82.40 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sintilimab |
| INN | sintilimab |
| Description | Sintilimab, sold under the brand Tyvyt among others, is a medication used to treat Hodgkin's disease, and has been approved in China.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 2072873-06-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297829 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15765 |
| UNII ID | 8FU7FQ8UPK (ChemIDplus, GSRS) |
Target
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Variants
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Safety
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Adverse Events
Top Adverse Reactions
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574 adverse events reported
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