Therapeutic Area | MeSH |
---|---|
cardiovascular diseases | D002318 |
nutritional and metabolic diseases | D009750 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ZOCOR | Organon | N-019766 RX | 1991-12-23 | 4 products, RLD |
FLOLIPID | TCG Fluent Pharma | N-206679 RX | 2016-04-21 | 2 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
JUVISYNC | Merck & Co | N-202343 DISCN | 2011-10-07 | 6 products, RLD |
Brand Name | Status | Last Update |
---|---|---|
ezetimibe and simvastatin | ANDA | 2025-03-03 |
flolipid | New Drug Application | 2023-02-09 |
simcor | New Drug Application | 2010-08-06 |
simvastatin | ANDA | 2025-03-18 |
simvastatin simvastatin | ANDA | 2022-08-22 |
vytorin | New Drug Application | 2024-11-20 |
zocor | New Drug Application | 2025-01-24 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | 1 | 2 |
Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | 1 | — | — | 1 |
Drug common name | Simvastatin |
INN | simvastatin |
Description | Simvastatin is a member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. It has a role as an EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor, a prodrug, an EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor, a ferroptosis inducer and a geroprotector. It is a delta-lactone, a fatty acid ester, a statin (semi-synthetic) and a member of hexahydronaphthalenes. It is functionally related to a lovastatin. |
Classification | Small molecule |
Drug class | enzyme inhibitors: antihyperlipidemics (HMG-CoA inhibitors) |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 |
PDB | — |
CAS-ID | 79902-63-9 |
RxCUI | — |
ChEMBL ID | CHEMBL1064 |
ChEBI ID | 9150 |
PubChem CID | 54454 |
DrugBank | DB00641 |
UNII ID | AGG2FN16EV (ChemIDplus, GSRS) |