Sylvant(siltuximab)
Sylvant (siltuximab) is an antibody pharmaceutical. Siltuximab was first approved as Sylvant on 2014-04-23. It is used to treat castleman disease in the USA. It has been approved in Europe to treat castleman disease. The pharmaceutical is active against interleukin-6.
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Events Timeline
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2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Sylvant
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| sylvant | Biologic Licensing Application | 2024-08-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| castleman disease | EFO_1001332 | D005871 | D47.Z2 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
siltuximab, Sylvant, EUSA Pharma (UK) Limited | |||
| 2121-04-23 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J2860 | Injection, siltuximab, 10 mg |
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 1 | — | 1 | — | — | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | 1 | — | — | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | — | — | 1 | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | 1 | — | — | 1 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | — | 1 | — | — | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | 1 | — | — | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Skin neoplasms | D012878 | EFO_0004198 | C44 | — | 1 | — | — | — | 1 |
| Chronic pain | D059350 | — | — | — | 1 | — | — | — | 1 |
| Neurofibromatoses | D017253 | — | Q85.00 | — | 1 | — | — | — | 1 |
| Neurilemmoma | D009442 | EFO_0000693 | — | — | 1 | — | — | — | 1 |
| Castleman disease | D005871 | EFO_1001332 | D47.Z2 | — | 1 | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cytokine release syndrome | D000080424 | — | D89.83 | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Siltuximab |
| INN | siltuximab |
| Description | Siltuximab (chimeric mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743070 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | T4H8FMA7IM (ChemIDplus, GSRS) |
Target
Agency Approved
IL6
IL6
Organism
Homo sapiens
Gene name
IL6
Gene synonyms
IFNB2
NCBI Gene ID
Protein name
interleukin-6
Protein synonyms
B-cell differentiation factor, B-cell stimulatory factor 2, BSF-2, CDF, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, Interferon beta-2, interleukin BSF-2
Uniprot ID
Mouse ortholog
Il6 (16193)
interleukin-6 (P08505)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,256 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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419 adverse events reported
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