Rapaflo, Silodyx(silodosin)
Rapaflo, Silodosin, Silodyx, Urorec (silodosin) is a small molecule pharmaceutical. Silodosin was first approved as Rapaflo on 2008-10-08. It is used to treat prostatic hyperplasia in the USA. It has been approved in Europe to treat prostatic hyperplasia. The pharmaceutical is active against alpha-1A adrenergic receptor. In addition, it is known to target alpha-1B adrenergic receptor and alpha-1D adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Rapaflo, Silodosin (discontinued: Silodosin)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| prostatic hyperplasia | EFO_0000284 | D011470 | N40 |
Agency Specific
FDA
EMA
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Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | 3 | 4 | 7 | 4 | 19 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | 3 | 4 | 6 | 4 | 18 |
| Ureteral calculi | D014514 | — | — | 2 | 2 | 1 | 3 | 2 | 9 |
| Ureterolithiasis | D053039 | EFO_1001228 | N20.1 | 2 | 2 | 1 | 3 | 2 | 9 |
| Calculi | D002137 | — | — | 1 | 2 | — | 2 | — | 5 |
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | — | — | 1 | 2 | 1 | 4 |
| Nocturia | D053158 | — | R35.1 | — | 1 | — | 1 | — | 2 |
| Hypertrophy | D006984 | EFO_0002460 | — | — | — | — | 1 | — | 1 |
| Neurogenic urinary bladder | D001750 | HP_0000011 | N31 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney calculi | D007669 | EFO_0004253 | N20 | 1 | 2 | 2 | — | 1 | 5 |
| Urolithiasis | D052878 | — | N20-N23 | — | 2 | 1 | — | — | 3 |
| Urinary calculi | D014545 | — | N20.9 | — | 2 | 1 | — | — | 3 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | — | 1 |
| Urination disorders | D014555 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrolithiasis | D053040 | — | N20.0 | 1 | 2 | — | — | 1 | 3 |
| Urinary retention | D016055 | — | R33 | — | 1 | — | — | 1 | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 1 | — | — | — | 1 |
| Premature ejaculation | D061686 | — | F52.4 | — | 1 | — | — | — | 1 |
| Prostatitis | D011472 | EFO_0003830 | N41 | — | 1 | — | — | — | 1 |
| Chronic disease | D002908 | — | — | — | 1 | — | — | — | 1 |
| Pelvic pain | D017699 | — | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | — | — | — | 1 | 1 |
| Pathologic dilatation | D004108 | — | — | — | — | — | — | 1 | 1 |
| Trichinellosis | D014235 | EFO_0007520 | B75 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Silodosin |
| INN | silodosin |
| Description | Silodosin is an indolecarboxamide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 160970-54-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL24778 |
| ChEBI ID | — |
| PubChem CID | 5312125 |
| DrugBank | DB06207 |
| UNII ID | CUZ39LUY82 (ChemIDplus, GSRS) |
Target
Agency Approved
ADRA1A
ADRA1A
Organism
Homo sapiens
Gene name
ADRA1A
Gene synonyms
ADRA1C
NCBI Gene ID
Protein name
alpha-1A adrenergic receptor
Protein synonyms
Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, G protein coupled receptor
Uniprot ID
Mouse ortholog
Adra1a (11549)
alpha-1A adrenergic receptor (Q8BV77)
Alternate
ADRA1B
ADRA1B
ADRA1D
ADRA1D
Variants
No data
Financial
Revenue by drug
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€
£
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Rapaflo – Allergan
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Rapaflo – Warner Chilcott
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Estimated US medical usage
Silodosin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,047 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,678 adverse events reported
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