Viagra(sildenafil)
Granpidam, Liqrev, Mysildecard, Revatio, Sildenafil, Viagra, Vizarsin (sildenafil) is a small molecule pharmaceutical. Sildenafil was first approved as Viagra on 1998-03-27. It is used to treat pulmonary hypertension and vasculogenic impotence in the USA. It has been approved in Europe to treat erectile dysfunction and pulmonary hypertension. The pharmaceutical is active against cGMP-specific 3',5'-cyclic phosphodiesterase. In addition, it is known to target ATP-binding cassette sub-family C member 5, cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', solute carrier organic anion transporter family member 2B1, and solute carrier organic anion transporter family member 1B3.
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Events Timeline
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Revatio, Sildenafil, Viagra (discontinued: Liqrev, Sildenafil)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| liqrev | New Drug Application | 2024-05-28 |
| revatio | New Drug Application | 2024-12-18 |
| sildenafil | ANDA | 2025-01-13 |
| sildenafil citrate | ANDA | 2025-01-03 |
| sildenafil for oral suspension | ANDA | 2020-08-15 |
| viagra | New Drug Application | 2023-11-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pulmonary hypertension | EFO_0001361 | D006976 | I27.20 |
| vasculogenic impotence | EFO_1001234 | D018783 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
SILDENAFIL CITRATE, REVATIO, VIATRIS | |||
| 2026-01-31 | M-287 | ||
HCPCS
Code | Description |
|---|---|
| S0090 | Sildenafil citrate, 25 mg |
Clinical
Clinical Trials
463 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 5 | — | — | 20 | 1 | 26 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 2 | 7 | 5 | 5 | 20 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | 5 | 4 | 6 | 16 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | 2 | 5 | 1 | 3 | 12 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | — | — | 2 | 4 | 2 | 8 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | 1 | — | 1 | — | 2 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | 1 | — | 1 | — | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | 1 | — | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | 1 | — | 1 |
| Spinal injuries | D013124 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Persistent fetal circulation syndrome | D010547 | EFO_1001103 | P29.3 | — | 2 | 1 | — | 1 | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psychological sexual dysfunctions | D020018 | — | F52.0 | — | 2 | — | — | — | 2 |
| Physiological sexual dysfunction | D012735 | — | — | — | 1 | — | — | — | 1 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | 1 | — | — | — | 1 |
| Eclampsia | D004461 | HP_0100601 | O15 | — | 1 | — | — | — | 1 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sildenafil |
| INN | sildenafil |
| Description | Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. It is unclear if it is effective for treating sexual dysfunction in women. It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or sublingually (dissolved under the tongue). Onset when taken orally is typically within twenty minutes and lasts for about two hours.
|
| Classification | Small molecule |
| Drug class | phosphodiesterase type 5 inhibitors (PDE5) inhibitors: (PDE5) inhibitors containing a sulfonamide moiety |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12 |
Identifiers
| PDB | — |
| CAS-ID | 139755-83-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL192 |
| ChEBI ID | 9139 |
| PubChem CID | 5212 |
| DrugBank | DB00203 |
| UNII ID | 3M7OB98Y7H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLCO2B1
SLCO2B1
Organism
Homo sapiens
Gene name
SLCO2B1
Gene synonyms
KIAA0880, OATP2B1, OATPB, SLC21A9
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 2B1
Protein synonyms
OATP-B, OATP-RP2, OATP2B1, OATPRP2, Organic anion transporter B, Organic anion transporter polypeptide-related protein 2, Organic anion transporting polypeptide 2B1, solute carrier family 21 (organic anion transporter), member 9, Solute carrier family 21 member 9
Uniprot ID
Mouse ortholog
Slco2b1 (101488)
solute carrier organic anion transporter family member 2B1 (Q8BXB6)
Variants
No data
Financial
Revenue by drug
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Revatio – Pfizer
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Sildenafil – Pfizer
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Viagra – Viatris
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Viagra – Pfizer
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Tabular view
Estimated US medical usage
Sildenafil
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22,488 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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58,147 adverse events reported
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