Sepranolone
Sepranolone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
35 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 1 | 2 | 1 | 2 | 3 | 9 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 2 | 1 | 2 | 3 | 8 |
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | — | 1 | 1 | 1 | 3 |
| Premenstrual dysphoric disorder | D065446 | — | F32.81 | 1 | 2 | — | 1 | — | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 2 | 1 | — | — | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | — | 1 | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | 1 | — | — | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | 1 | — | — | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 2 | — | — | 1 | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 2 | 1 | — | — | — | 3 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 3 | — | — | — | 3 |
| Brain injuries | D001930 | — | S06.9 | — | 3 | — | — | — | 3 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 2 | — | — | — | 2 |
| Traumatic stress disorders | D040921 | — | — | — | 2 | — | — | — | 2 |
| Premenstrual syndrome | D011293 | — | N94.3 | 1 | 1 | — | — | — | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | 1 | 2 |
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | — | — | 2 |
| Ataxia | D001259 | — | R27.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 1 | — | — | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | — | — | — | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | — | — | — | — | 1 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Seizures | D012640 | — | G40.4 | — | — | — | — | 1 | 1 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | — | 1 | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sepranolone |
| INN | sepranolone |
| Description | 3beta-hydroxy-5alpha-pregnan-20-one is a 3-hydroxy-5alpha-pregnan-20-one. |
| Classification | Small molecule |
| Drug class | steroids (not prednisolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |
Identifiers
| PDB | — |
| CAS-ID | 516-55-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2057301 |
| ChEBI ID | 11909 |
| PubChem CID | 92787 |
| DrugBank | — |
| UNII ID | 3P8Z6V53MU (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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