Semustine
Semustine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematopoietic stem cell transplantation | D018380 | — | — | 1 | 1 | 2 | 1 | 3 | 7 |
| Graft vs host disease | D006086 | — | D89.81 | — | 1 | — | 1 | — | 2 |
| Virus diseases | D014777 | — | B34 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | — | 6 | 6 | — | 1 | 9 |
| Hematologic neoplasms | D019337 | — | — | — | — | 1 | — | 3 | 4 |
| Recurrence | D012008 | — | — | — | 2 | 3 | — | 1 | 4 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | 2 | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | — | 2 | 2 | — | — | 2 |
| Classical conditioning | D003214 | — | — | — | 1 | 1 | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | 1 | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | — | 1 | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | — | 1 | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | — | 2 | — | — | 1 | 3 |
| Preleukemia | D011289 | — | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | — | — | — | 2 | 2 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Semustine |
| INN | semustine |
| Description | Semustine is an organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group. It has a role as an antineoplastic agent, a carcinogenic agent and an alkylating agent. It is an organochlorine compound and a member of N-nitrosoureas. |
| Classification | Small molecule |
| Drug class | antineoplastics (chloroethylamine derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1CCC(NC(=O)N(CCCl)N=O)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 13909-09-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL12948 |
| ChEBI ID | 6863 |
| PubChem CID | 5198 |
| DrugBank | — |
| UNII ID | 6YY7T1T567 (ChemIDplus, GSRS) |
Target
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Trends
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Additional graphs summarizing 435 documents
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Safety
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Adverse Events
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151 adverse events reported
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