Semustine
Semustine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | — | — | 1 | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Semustine |
| INN | semustine |
| Description | Semustine is an organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group. It has a role as an antineoplastic agent, a carcinogenic agent and an alkylating agent. It is an organochlorine compound and a member of N-nitrosoureas. |
| Classification | Small molecule |
| Drug class | antineoplastics (chloroethylamine derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1CCC(NC(=O)N(CCCl)N=O)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 13909-09-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL12948 |
| ChEBI ID | 6863 |
| PubChem CID | 5198 |
| DrugBank | — |
| UNII ID | 6YY7T1T567 (ChemIDplus, GSRS) |
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Trends
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Safety
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171 adverse events reported
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