Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colorectal neoplasms | D015179 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
Kaposi sarcoma | D012514 | — | C46 | 1 | — | — | — | — | 1 |
Drug common name | Semaxanib |
INN | semaxanib |
Description | Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis modulating agent. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole. |
Classification | Small molecule |
Drug class | angiogenesis inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1 |
PDB | — |
CAS-ID | 194413-58-6 |
RxCUI | — |
ChEMBL ID | CHEMBL276711 |
ChEBI ID | — |
PubChem CID | 5329098 |
DrugBank | — |
UNII ID | 71IA9S35AJ (ChemIDplus, GSRS) |