Retevmo, Retsevmo(selpercatinib)
Retevmo, Retsevmo (selpercatinib) is a small molecule pharmaceutical. Selpercatinib was first approved as Retevmo on 2020-05-08. It is used to treat non-small-cell lung carcinoma and thyroid neoplasms in the USA. It has been approved in Europe to treat non-small-cell lung carcinoma and thyroid neoplasms. It is known to target proto-oncogene tyrosine-protein kinase receptor Ret.
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Start date
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Retevmo
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| retevmo | New Drug Application | 2025-07-18 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-small-cell lung carcinoma | — | D002289 | — |
| thyroid neoplasms | EFO_0003841 | D013964 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
SELPERCATINIB, RETEVMO, LOXO ONCOL ELI LILLY | |||
| 2029-09-21 | ODE-409, ODE-412 | ||
| 2027-05-08 | ODE-301, ODE-302, ODE-303 | ||
| 2025-05-08 | NCE | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Selpercatinib, Retevmo, Loxo Oncol Eli Lilly | |||
| 10584124 | 2038-10-10 | DP | U-2826, U-2827, U-2828, U-3450, U-3451, U-3452, U-3453 |
| 10786489 | 2038-10-10 | DP | U-2971, U-2972, U-2973, U-2974, U-2975, U-2976, U-2977, U-3450, U-3451, U-3452, U-3453 |
| 10112942 | 2037-10-10 | DS, DP | |
| 10137124 | 2037-10-10 | U-2826, U-2827, U-2828, U-3450, U-3451, U-3452, U-3453 | |
| 10172851 | 2037-10-10 | U-2826, U-2827, U-2828, U-3450, U-3451, U-3452, U-3453 | |
HCPCS
No data
Clinical
Clinical Trials
37 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 2 | 5 | 1 | — | 1 | 7 |
| Papillary thyroid cancer | D000077273 | — | — | 2 | 4 | 1 | — | 1 | 6 |
| Thyroid diseases | D013959 | — | E00-E07 | 2 | 4 | 1 | — | 1 | 6 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | 2 | — | 1 | 4 |
| Neuroendocrine carcinoma | D018278 | — | — | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 1 | 4 | — | — | 1 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | 1 | 2 |
| Colonic neoplasms | D003110 | — | C18 | 1 | 1 | — | — | 1 | 2 |
| Brain stem neoplasms | D020295 | EFO_1001767 | — | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | 1 | — | — | — | 1 |
| Fibrosarcoma | D005354 | — | — | 1 | 1 | — | — | — | 1 |
| Myofibromatosis | D018224 | — | — | 1 | 1 | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 15 | — | — | — | — | 15 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Selpercatinib |
| INN | selpercatinib |
| Description | Selpercatinib, sold under the brand name Retevmo among others, is a medication for the treatment of cancers in people whose tumors have an alteration (mutation or fusion) in a specific gene (RET which is short for "rearranged during transfection"). It is taken by mouth.
|
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 2152628-33-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4559134 |
| ChEBI ID | — |
| PubChem CID | 134436906 |
| DrugBank | DB15685 |
| UNII ID | CEGM9YBNGD (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RET
RET
Organism
Homo sapiens
Gene name
RET
Gene synonyms
CDHF12, CDHR16, PTC
NCBI Gene ID
Protein name
proto-oncogene tyrosine-protein kinase receptor Ret
Protein synonyms
Cadherin family member 12, cadherin-related family member 16, Proto-oncogene c-Ret, rearranged during transfection, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), RET receptor tyrosine kinase
Uniprot ID
Mouse ortholog
Ret (19713)
proto-oncogene tyrosine-protein kinase receptor Ret (P35546)
Variants
No data
Financial
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Trends
PubMed Central
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Additional graphs summarizing 1,740 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,095 adverse events reported
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