Selonsertib
Selonsertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase kinase kinase 5.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
No data
Clinical
Clinical Trials
11 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 3 | 2 | — | — | 5 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 3 | 2 | — | — | 5 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic nephropathies | D003928 | EFO_0000401 | — | 1 | 2 | — | — | — | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 2 | — | — | — | 3 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | — | — | — | 1 |
| Hepatitis | D006505 | — | K75.9 | — | 1 | — | — | — | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 1 | — | — | — | 1 |
| Alcoholic hepatitis | D006519 | EFO_1001345 | K70.1 | — | 1 | — | — | — | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | 1 | — | — | — | 1 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | — | 1 | — | — | — | 1 |
| Fibrosis | D005355 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Selonsertib |
| INN | selonsertib |
| Description | Selonsertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase kinase kinase 5. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1448428-04-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3916717 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | NS3988A2TC (ChemIDplus, GSRS) |
Target
Agency Approved
MAP3K5
MAP3K5
Organism
Homo sapiens
Gene name
MAP3K5
Gene synonyms
ASK1, MAPKKK5, MEKK5
NCBI Gene ID
Protein name
mitogen-activated protein kinase kinase kinase 5
Protein synonyms
Apoptosis signal-regulating kinase 1, ASK-1, MAP/ERK kinase kinase 5, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
Uniprot ID
Mouse ortholog
Map3k5 (26408)
mitogen-activated protein kinase kinase kinase 5 (Q14AY5)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 1,048 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
16 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use