Selegiline
Emsam, Selegiline, Zelapar (selegiline) is a small molecule pharmaceutical. Selegiline was first approved as Selegiline hydrochloride on 1989-06-05. It is used to treat alzheimer disease, attention deficit disorder with hyperactivity, depressive disorder, parkinson disease, and schizophrenia in the USA. The pharmaceutical is active against amine oxidase [flavin-containing] B. In addition, it is known to target amine oxidase [flavin-containing] A.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Emsam, Selegiline, Zelapar (discontinued: Eldepryl, Selegiline)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Selegiline hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZELAPAR | Bausch Health Companies | N-021479 RX | 2006-06-14 | 1 products, RLD, RS |
Show 2 discontinued
Selegiline
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EMSAM | Somerset Pharma | N-021336 RX | 2006-02-27 | 3 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| emsam | New Drug Application | 2020-05-15 |
| selegiline hydrochloride | ANDA | 2025-09-22 |
| zelapar | New Drug Application | 2021-06-01 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | 2 | — | 2 |
| Depression | D003863 | — | F33.9 | — | — | 1 | 1 | — | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 1 | 1 | — | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | 1 | 1 | — | 2 |
| Tissue adhesions | D000267 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Selegiline |
| INN | selegiline |
| Description | (-)-selegiline is a selegiline and a terminal acetylenic compound. It has a role as a geroprotector. It is a conjugate base of a (-)-selegiline(1+). |
| Classification | Small molecule |
| Drug class | Monoamine oxidase (MAO) inhibitors, type B |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C#CCN(C)[C@H](C)Cc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 14611-51-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL972 |
| ChEBI ID | 9086 |
| PubChem CID | 26757 |
| DrugBank | DB01037 |
| UNII ID | 2K1V7GP655 (ChemIDplus, GSRS) |
Target
Agency Approved
MAOB
MAOB
Variants
No data
Financial
Revenue by drug
$
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Estimated US medical usage
Selegiline
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,630 documents
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Safety
Black-box Warning
Black-box warning for: Emsam
Adverse Events
Top Adverse Reactions
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2,288 adverse events reported
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