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Drug ReportsScopolamine
Scopolamine
Scopolamine, Transderm Scop (scopolamine) is a small molecule pharmaceutical. Scopolamine was first approved as Transderm scop on 1982-01-01. It is used to treat colonic diseases, diverticulitis, dysentery, facial paralysis, and iridocyclitis amongst others in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M1 and muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M5.
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Variants
Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
stomatognathic diseasesD009057
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
nervous system diseasesD009422
eye diseasesD005128
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Scopolamine, Transderm scop
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Scopolamine
Tradename
Company
Number
Date
Products
TRANSDERM SCOPBaxterN-017874 RX1982-01-01
1 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
atenolol scopolamineunapproved drug other2014-10-15
donnatalunapproved drug other2024-12-05
donnatal extentabsunapproved drug other2011-10-17
kimiteunapproved drug other2018-12-12
phenobarbital, hyoscyamine sulfate, atropine sulfate and scopolamine hydrobromideunapproved drug other2023-01-10
phenobarbital, hyoscyamine sulfate, atropine sulfate, scopolamine hydrobromideunapproved drug other2023-01-12
phenohytrounapproved drug other2025-05-23
propranolol scopolamineunapproved drug other2014-10-15
quadrapaxunapproved drug other2011-09-13
scopolamineANDA2025-08-23
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
A04: Antiemetics and antinauseants
A04A: Antiemetics and antinauseants
A04AD: Other antiemetics in atc
A04AD01: Scopolamine
A04AD51: Scopolamine, combinations
N: Nervous system drugs
N05: Psycholeptics
N05C: Hypnotics and sedatives
N05CM: Other hypnotics and sedatives in atc
N05CM05: Scopolamine
S: Sensory organ drugs
S01: Ophthalmologicals
S01F: Mydriatics and cycloplegics
S01FA: Anticholinergic mydriatics and cycloplegics
S01FA02: Scopolamine
HCPCS
No data
Clinical
Clinical Trials
438 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.91438856739240
Lung diseasesD008171EFO_0003818J98.4829663724162
Obstructive lung diseasesD008173620443318118
AsthmaD001249EFO_0000270J45211106534
Healthy volunteers/patients2011224
Respiratory aspirationD053120EFO_10018393282116
NauseaD009325R11.0369
PainD010146EFO_0003843R5211439
VomitingD014839R11.1358
Postoperative nausea and vomitingD020250EFO_0004888246
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Motion sicknessD009041T75.324913
DysmenorrheaD004412N94.6112
Cardiovascular diseasesD002318EFO_0000319I98112
Colorectal neoplasmsD015179112
Obstetric laborD007743112
Rectal neoplasmsD012004112
Cerebral palsyD002547G8011
Neuroendocrine tumorsD018358EFO_1001901D3A.8111
Acute abdomenD000006R10.011
Labor painD048949111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cognitive dysfunctionD060825G31.84415
Alzheimer diseaseD000544EFO_0000249F0344
Memory disordersD008569213
DementiaD003704EFO_0003862F0333
Organophosphate poisoningD062025112
PoisoningD011041EFO_0008546T65.91112
HallucinationsD006212F06.011
Psychotic disordersD011618F20.8111
Renal colicD056844EFO_1001412N2311
Nerve degenerationD00941011
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Disease progressionD01845011
RhytidoplastyD01536111
DeliriumD003693R41.011
Systemic sclerodermaD012595EFO_0000717M3411
Diffuse sclerodermaD045743EFO_000040411
SclerosisD01259811
ObesityD009765EFO_0001073E66.911
InflammationD007249MP_000184511
Bronchial hyperreactivityD01653511
CholedocholithiasisD042883EFO_100086511
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameScopolamine
INN
Description
[(1S,5R)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate is a 3-hydroxy carboxylic acid.
Classification
Small molecule
Drug class Antimuscarinic Deliriant Antiemetic Amnestic
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21
Identifiers
PDB
CAS-ID51-34-3
RxCUI
ChEMBL IDCHEMBL569713
ChEBI ID16794
PubChem CID153311
DrugBankDB00747
UNII ID
Target
Agency Approved
CHRM1
CHRM1
CHRM3
CHRM3
Organism
Homo sapiens
Gene name
CHRM1
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M1
Protein synonyms
acetylcholine receptor, muscarinic 1
Uniprot ID
Mouse ortholog
Chrm1 (12669)
muscarinic acetylcholine receptor M1 (Q8BJN3)
Alternate
CHRM2
CHRM2
CHRM4
CHRM4
CHRM5
CHRM5
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Scopolamine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 24,779 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,846 adverse events reported
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