Scopolamine
Scopolamine, Transderm Scop (scopolamine) is a small molecule pharmaceutical. Scopolamine was first approved as Transderm scop on 1982-01-01. It is used to treat colonic diseases, diverticulitis, dysentery, facial paralysis, and iridocyclitis amongst others in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M1 and muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M4, and muscarinic acetylcholine receptor M5.
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Commercial
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Scopolamine, Transderm scop
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atenolol scopolamine | unapproved drug other | 2014-10-15 |
| donnatal | unapproved drug other | 2024-12-05 |
| donnatal extentabs | unapproved drug other | 2011-10-17 |
| kimite | unapproved drug other | 2018-12-12 |
| phenobarbital, hyoscyamine sulfate, atropine sulfate and scopolamine hydrobromide | unapproved drug other | 2023-01-10 |
| phenobarbital, hyoscyamine sulfate, atropine sulfate, scopolamine hydrobromide | unapproved drug other | 2023-01-12 |
| phenohytro | unapproved drug other | 2025-05-23 |
| propranolol scopolamine | unapproved drug other | 2014-10-15 |
| quadrapax | unapproved drug other | 2011-09-13 |
| scopolamine | ANDA | 2025-08-23 |
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A04: Antiemetics and antinauseants
— A04A: Antiemetics and antinauseants
— A04AD: Other antiemetics in atc
— A04AD01: Scopolamine
— A04AD51: Scopolamine, combinations
N: Nervous system drugs
— N05: Psycholeptics
— N05C: Hypnotics and sedatives
— N05CM: Other hypnotics and sedatives in atc
— N05CM05: Scopolamine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01F: Mydriatics and cycloplegics
— S01FA: Anticholinergic mydriatics and cycloplegics
— S01FA02: Scopolamine
HCPCS
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Clinical
Clinical Trials
438 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 14 | 38 | 85 | 67 | 39 | 240 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 8 | 29 | 66 | 37 | 24 | 162 |
| Obstructive lung diseases | D008173 | — | — | 6 | 20 | 44 | 33 | 18 | 118 |
| Asthma | D001249 | EFO_0000270 | J45 | 2 | 11 | 10 | 6 | 5 | 34 |
| Healthy volunteers/patients | — | — | — | 20 | 1 | 1 | 2 | — | 24 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | 3 | 2 | 8 | 2 | 1 | 16 |
| Nausea | D009325 | — | R11.0 | — | — | — | 3 | 6 | 9 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | 1 | — | 4 | 3 | 9 |
| Vomiting | D014839 | — | R11.1 | — | — | — | 3 | 5 | 8 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | 2 | 4 | 6 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Motion sickness | D009041 | — | T75.3 | 2 | 4 | 9 | — | — | 13 |
| Dysmenorrhea | D004412 | — | N94.6 | — | — | 1 | — | 1 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | 1 | 2 |
| Colorectal neoplasms | D015179 | — | — | — | — | 1 | — | 1 | 2 |
| Obstetric labor | D007743 | — | — | — | — | 1 | — | 1 | 2 |
| Rectal neoplasms | D012004 | — | — | — | — | 1 | — | 1 | 2 |
| Cerebral palsy | D002547 | — | G80 | — | — | 1 | — | — | 1 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 1 | 1 | — | — | 1 |
| Acute abdomen | D000006 | — | R10.0 | — | — | 1 | — | — | 1 |
| Labor pain | D048949 | — | — | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 2 | — | — | 1 | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | — | — | 3 |
| Gastrointestinal diseases | D005767 | — | — | — | 1 | — | — | 1 | 2 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | 1 | — | — | 1 | 2 |
| Acute pain | D059787 | — | R52 | — | 1 | — | — | 1 | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 1 | — | — | 1 | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | 1 | — | — | — | 2 |
| Space motion sickness | D018489 | EFO_1001188 | — | — | 2 | — | — | — | 2 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | 1 | — | — | — | 1 |
| Sialorrhea | D012798 | — | K11.7 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognitive dysfunction | D060825 | — | G31.84 | 4 | — | — | — | 1 | 5 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 4 | — | — | — | — | 4 |
| Memory disorders | D008569 | — | — | 2 | — | — | — | 1 | 3 |
| Dementia | D003704 | EFO_0003862 | F03 | 3 | — | — | — | — | 3 |
| Organophosphate poisoning | D062025 | — | — | 1 | — | — | — | 1 | 2 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | 1 | — | — | — | 1 | 2 |
| Hallucinations | D006212 | — | F06.0 | 1 | — | — | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | 1 | — | — | — | — | 1 |
| Renal colic | D056844 | EFO_1001412 | N23 | 1 | — | — | — | — | 1 |
| Nerve degeneration | D009410 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
| Rhytidoplasty | D015361 | — | — | — | — | — | — | 1 | 1 |
| Delirium | D003693 | — | R41.0 | — | — | — | — | 1 | 1 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | — | — | 1 | 1 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | — | — | — | 1 | 1 |
| Sclerosis | D012598 | — | — | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Bronchial hyperreactivity | D016535 | — | — | — | — | — | — | 1 | 1 |
| Choledocholithiasis | D042883 | EFO_1000865 | — | — | — | — | — | 1 | 1 |
Show 28 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Scopolamine |
| INN | — |
| Description | [(1S,5R)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate is a 3-hydroxy carboxylic acid. |
| Classification | Small molecule |
| Drug class | Antimuscarinic Deliriant Antiemetic Amnestic |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1[C@H]2C[C@H](OC(=O)[C@H](CO)c3ccccc3)C[C@@H]1[C@H]1O[C@@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 51-34-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL569713 |
| ChEBI ID | 16794 |
| PubChem CID | 153311 |
| DrugBank | DB00747 |
| UNII ID | — |
Target
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CHRM2
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Scopolamine
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Safety
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5,303 adverse events reported
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