Therapeutic Area | MeSH |
---|---|
nutritional and metabolic diseases | D009750 |
endocrine system diseases | D004700 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
QTERNMET XR | AstraZeneca | N-210874 DISCN | 2019-05-02 | 4 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
QTERN | AstraZeneca | N-209091 RX | 2017-02-27 | 2 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
KOMBIGLYZE XR | AstraZeneca | N-200678 DISCN | 2010-11-05 | 3 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ONGLYZA | AstraZeneca | N-022350 DISCN | 2009-07-31 | 2 products, RLD |
Brand Name | Status | Last Update |
---|---|---|
qtern | New Drug Application | 2023-09-29 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Expiration | Code | ||
---|---|---|---|
SAXAGLIPTIN HYDROCHLORIDE, SAXAGLIPTIN, AMNEAL | |||
2024-01-27 | PC | ||
SAXAGLIPTIN HYDROCHLORIDE, SAXAGLIPTIN, AUROBINDO PHARMA | |||
2024-01-27 | PC |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Dapagliflozin / Metformin Hydrochloride / Saxagliptin Hydrochloride, Qternmet Xr, Astrazeneca Ab | |||
9616028 | 2030-11-12 | DP | |
7919598 | 2029-12-16 | DP | |
8716251 | 2028-03-21 | DP | |
8501698 | 2027-06-20 | DP | U-493, U-1976, U-1977 |
6515117 | 2025-10-04 | DS, DP | U-493 |
8628799 | 2025-07-13 | DP | |
Saxagliptin Hydrochloride, Onglyza, Astrazeneca Ab | |||
7951400 | 2028-11-30 | DP | |
Dapagliflozin / Saxagliptin Hydrochloride, Qtern, Astrazeneca Ab | |||
8221786 | 2028-03-21 | DP | |
8361972 | 2028-03-21 | U-493, U-1976, U-1977 | |
Metformin Hydrochloride / Saxagliptin Hydrochloride, Kombiglyze Xr, Astrazeneca Ab | |||
9339472 | 2025-07-13 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 16 | 5 | 33 | 32 | 34 | 119 |
Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | 3 | 2 | 5 |
Heart failure | D006333 | HP_0001635 | I50 | — | — | — | 3 | 1 | 4 |
Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 2 | — | — | 2 | — | 4 |
Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | 1 | 2 | — | 4 |
Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | 1 | 1 | 3 |
Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 3 | — | 3 |
Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | 2 | — | 2 |
Coronary artery disease | D003324 | — | I25.1 | — | — | — | 1 | — | 1 |
Hypertriglyceridemia | D015228 | EFO_0004211 | — | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | 1 | — | — | 1 |
Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | 1 | — | — | 1 |
Hypoglycemia | D007003 | HP_0001943 | E16.2 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Fragile x syndrome | D005600 | — | Q99.2 | 1 | 1 | — | — | — | 1 |
Insulin resistance | D007333 | HP_0000855 | E88.819 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Exercise | D015444 | EFO_0000483 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | — | 2 | 2 |
Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 1 | 1 |
Diabetic ketoacidosis | D016883 | EFO_1000897 | — | — | — | — | — | 1 | 1 |
Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 1 | 1 |
Endoplasmic reticulum stress | D059865 | EFO_1001886 | — | — | — | — | — | 1 | 1 |
Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | — | — | — | — | 1 | 1 |
Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Saxagliptin |
INN | saxagliptin |
Description | Saxagliptin is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes. It has a role as a hypoglycemic agent and an EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor. It is a member of adamantanes, a nitrile, an azabicycloalkane, a tertiary alcohol and a monocarboxylic acid amide. |
Classification | Small molecule |
Drug class | dipeptidyl aminopeptidase-IV inhibitors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | N#C[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)[C@@H](N)C12CC3CC(CC(O)(C3)C1)C2.O |
PDB | — |
CAS-ID | 945667-22-1 |
RxCUI | — |
ChEMBL ID | CHEMBL2103745 |
ChEBI ID | 71271 |
PubChem CID | 11243969 |
DrugBank | DB06335 |
UNII ID | 8I7IO46IVQ (ChemIDplus, GSRS) |