Entresto(sacubitril)
Entresto, Neparvis, Sacubitril / Valsartan (sacubitril) is a small molecule pharmaceutical. Sacubitril was first approved as Entresto on 2015-07-07. It has been approved in Europe to treat heart failure.
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FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Combinations
Entresto, Sacubitril valsartan
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| entresto | New Drug Application | 2025-08-12 |
| sacubitril and valsartan | ANDA | 2025-09-03 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| heart failure | EFO_0003144 | D006333 | I50 |
| diabetic nephropathies | EFO_0000401 | D003928 | — |
| hypertension | EFO_0000537 | D006973 | I10 |
| left ventricular dysfunction | — | D018487 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
SACUBITRIL / VALSARTAN, ENTRESTO, NOVARTIS PHARMS CORP | |||
| 2024-02-16 | M-82 | ||
HCPCS
No data
Clinical
Clinical Trials
206 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sacubitril |
| INN | sacubitril |
| Description | Sacubitril is a member of biphenyls. |
| Classification | Small molecule |
| Drug class | endopeptidase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 149709-62-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137301 |
| ChEBI ID | — |
| PubChem CID | 9811834 |
| DrugBank | DB09292 |
| UNII ID | 17ERJ0MKGI (ChemIDplus, GSRS) |
Target
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Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Entresto – Novartis
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Tabular view
Estimated US medical usage
Sacubitril
+
Valsartan
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,309 documents
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Safety
Black-box Warning
Black-box warning for: Entresto, Sacubitril and valsartan
Adverse Events
Top Adverse Reactions
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112,575 adverse events reported
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