SOTRASTAURIN
Sotrastaurin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against protein kinase C delta type, protein kinase C theta type, protein kinase C eta type, protein kinase C epsilon type, protein kinase C alpha type, and protein kinase C beta type.
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Commercial
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Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | 2 | 6 | — | — | — | 6 |
| Melanoma | D008545 | — | — | 3 | 1 | — | — | — | 3 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | 3 | 1 | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 2 | 1 | — | — | — | 3 |
| Liver transplantation | D016031 | EFO_0010682 | — | 1 | 1 | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | — | 1 | — | — | — | 1 |
| Prolymphocytic leukemia | D015463 | — | — | — | 1 | — | — | — | 1 |
| Mantle-cell lymphoma | D020522 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 2 | — | — | — | — | 2 |
| B-cell lymphoma | D016393 | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SOTRASTAURIN |
| INN | sotrastaurin |
| Description | Sotrastaurin is a member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, an immunosuppressive agent and an anticoronaviral agent. It is a N-alkylpiperazine, a N-arylpiperazine, a member of indoles, a member of quinazolines and a member of maleimides. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 425637-18-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL565612 |
| ChEBI ID | 90531 |
| PubChem CID | 10296883 |
| DrugBank | — |
| UNII ID | 7I279E1NZ8 (ChemIDplus, GSRS) |
Target
Agency Approved
PRKCD
PRKCD
PRKCQ
PRKCQ
PRKCH
PRKCH
PRKCE
PRKCE
PRKCA
PRKCA
PRKCB
PRKCB
Alternate
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Variants
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Trends
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Safety
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144 adverse events reported
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