SOLABEGRON
Solabegron is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against beta-3 adrenergic receptor. In addition, it is known to target beta-1 adrenergic receptor and beta-2 adrenergic receptor.
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Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 2 | 1 | — | — | — | 3 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | 1 | 1 | — | — | — | 2 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SOLABEGRON |
| INN | solabegron |
| Description | Solabegron is a carboxybiphenyl that is [biphenyl]-3-carboxylic acid carrying a (2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)nitrilo group at the 3' position. A selective beta3-adrenergic receptor agonist currently in clinical development for the treatment of overactive bladder and irritable bowel syndrome. It has a role as a beta-adrenergic agonist. It is a secondary alcohol, a substituted aniline, a member of monochlorobenzenes, a secondary amino compound and a carboxybiphenyl. |
| Classification | Small molecule |
| Drug class | beta3 adrenoreceptor agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)c1cccc(-c2cccc(NCCNC[C@H](O)c3cccc(Cl)c3)c2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 252920-94-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL208427 |
| ChEBI ID | — |
| PubChem CID | 9887812 |
| DrugBank | DB06190 |
| UNII ID | 55P6YH9O6N (ChemIDplus, GSRS) |
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Safety
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Adverse Events
0 adverse events reported
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