SELURAMPANEL
Selurampanel is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Seizures | D012640 | HP_0002069 | G40.4 | — | 4 | — | — | — | 4 |
| Complex partial epilepsy | D017029 | EFO_1000877 | — | — | 3 | — | — | — | 3 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 2 | — | — | — | 2 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 2 | — | — | — | 2 |
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Adenoma | D000236 | — | — | — | 1 | — | — | — | 1 |
| Adrenocortical adenoma | D018246 | — | — | — | 1 | — | — | — | 1 |
| Endometrial stromal sarcoma | D018203 | — | — | — | 1 | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | — | — | — | 1 |
| Muscle spasticity | D009128 | HP_0001257 | — | — | 1 | — | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SELURAMPANEL |
| INN | selurampanel |
| Description | Selurampanel (INN, code name BGG492) is a drug closely related to the quinoxalinedione series which acts as a competitive antagonist of the AMPA and kainate receptors and, as of 2015, is being investigated in clinical trials by Novartis for the treatment of epilepsy. It has also been studied in the acute treatment of migraine, and was found to produce some pain relief, but with a relatively high rate of side effects.
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| Classification | Small molecule |
| Drug class | ionotropic non-NMDA (N-methyl D-aspartate) glutamate receptors [AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) and/or KA (kainite antagonist) receptors]: antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)c1cc2[nH]c(=O)n(NS(C)(=O)=O)c(=O)c2cc1-c1ccnn1C |
Identifiers
| PDB | — |
| CAS-ID | 912574-69-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545042 |
| ChEBI ID | — |
| PubChem CID | 45381907 |
| DrugBank | — |
| UNII ID | 7WG1MR7DAR (ChemIDplus, GSRS) |
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Additional graphs summarizing 46 documents
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Safety
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Adverse Events
0 adverse events reported
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