SALIRASIB
Salirasib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target transient receptor potential cation channel subfamily A member 1.
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FDA approval date
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Study first post date
Last update post date
Start date
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Commercial
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 3 | 3 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 2 | 2 |
| Opiate overdose | D000083682 | — | — | — | — | — | — | 2 | 2 |
| Drug overdose | D062787 | — | — | — | — | — | — | 2 | 2 |
| Harm reduction | D040261 | — | — | — | — | — | — | 2 | 2 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 2 | 2 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | — | — | 1 | 1 |
| Eclampsia | D004461 | — | O15 | — | — | — | — | 1 | 1 |
| Digeorge syndrome | D004062 | — | D82.1 | — | — | — | — | 1 | 1 |
| Trisomy | D014314 | — | Q92.2 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SALIRASIB |
| INN | salirasib |
| Description | Salirasib is a sesquiterpenoid. |
| Classification | Small molecule |
| Drug class | Kirsten rat sarcoma (KRAS) inhibitors; anti-inflammatory agents (salicylic acid derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)=CCC/C(C)=C/CC/C(C)=C/CSc1ccccc1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 162520-00-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL23293 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12681 |
| UNII ID | MZH0OM550M (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
TRPA1
TRPA1
Organism
Homo sapiens
Gene name
TRPA1
Gene synonyms
ANKTM1
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily A member 1
Protein synonyms
ankyrin-like with transmembrane domains 1, Ankyrin-like with transmembrane domains protein 1, p120, Transformation-sensitive protein p120, Wasabi receptor
Uniprot ID
Mouse ortholog
Trpa1 (277328)
transient receptor potential cation channel subfamily A member 1 (Q8BLA8)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 431 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16 adverse events reported
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