Rucaparib
Rubraca (rucaparib) is a small molecule pharmaceutical. Rucaparib was first approved as Rubraca on 2016-12-19. It is used to treat ovarian neoplasms in the USA. It has been approved in Europe to treat ovarian neoplasms. The pharmaceutical is active against poly [ADP-ribose] polymerase 1.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| rubraca | New Drug Application | 2024-02-21 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
RUCAPARIB CAMSYLATE, RUBRACA, ZR PHARMA | |||
| 2025-04-06 | ODE-168 | ||
| 2023-12-19 | ODE-126 | ||
| 2023-05-15 | I-830 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Rucaparib Camsylate, Rubraca, Zr Pharma | |||
| 9987285 | 2035-08-17 | DP | |
| 10130636 | 2035-08-17 | U-2012, U-2101, U-2273, U-2830 | |
| 8859562 | 2031-08-04 | U-2012, U-2273, U-2830 | |
| 8754072 | 2031-02-10 | DS, DP | |
| 9045487 | 2031-02-10 | DS, DP | |
| 9861638 | 2031-02-10 | U-2012, U-2273 | |
| 10278974 | 2031-02-10 | DP | |
| 8071579 | 2027-08-12 | U-2012, U-2273, U-2830 | |
| 8143241 | 2027-08-12 | U-2012, U-2273, U-2830 | |
| 7351701 | 2024-07-23 | U-2012, U-2273, U-2830 | |
| 7531530 | 2024-07-23 | U-2012, U-2273, U-2830 | |
| 6495541 | 2023-11-22 | DS, DP | |
HCPCS
No data
Clinical
Clinical Trials
68 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 10 | 7 | 2 | — | 3 | 19 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 6 | 6 | 5 | — | — | 14 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 4 | 5 | 5 | — | 1 | 13 |
| Fallopian tube neoplasms | D005185 | — | — | 4 | 5 | 5 | — | 1 | 13 |
| Prostatic neoplasms | D011471 | — | C61 | 5 | 7 | 2 | — | — | 12 |
| Peritoneal neoplasms | D010534 | — | — | 2 | 3 | 3 | — | — | 7 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 2 | 3 | 3 | — | — | 7 |
| Adenocarcinoma | D000230 | — | — | 2 | 4 | 1 | — | — | 5 |
| Clear cell adenocarcinoma | D018262 | — | — | — | — | 1 | — | — | 1 |
| Large cell carcinoma | D018287 | — | — | — | — | 1 | — | — | 1 |
Show 1 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 3 | — | — | — | 6 |
| Carcinoma | D002277 | — | C80.0 | 2 | 5 | — | — | — | 6 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | 4 | — | — | — | 4 |
| Triple negative breast neoplasms | D064726 | — | — | 3 | 2 | — | — | — | 4 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 3 | — | — | — | 3 |
| Hereditary breast and ovarian cancer syndrome | D061325 | — | — | 1 | 2 | — | — | — | 3 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 3 | — | — | — | 3 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 3 | — | — | — | 3 |
| Carcinosarcoma | D002296 | — | — | 1 | 1 | — | — | — | 2 |
Show 29 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Female genital neoplasms | D005833 | — | — | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancytopenia | D010198 | HP_0001876 | D61.81 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | — | — | — | — | 1 | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | — | — | — | 1 | 1 |
| Preleukemia | D011289 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Rucaparib |
| INN | rucaparib |
| Description | Rucaparib is a member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an antineoplastic agent. It is an azepinoindole, a member of caprolactams, an organofluorine compound and a secondary amino compound. It is a conjugate base of a rucaparib(1+). |
| Classification | Small molecule |
| Drug class | poly-ADP-ribose polymerase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 283173-50-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1173055 |
| ChEBI ID | — |
| PubChem CID | 9931954 |
| DrugBank | DB12332 |
| UNII ID | 8237F3U7EH (ChemIDplus, GSRS) |
Target
Agency Approved
PARP1
PARP1
Organism
Homo sapiens
Gene name
PARP1
Gene synonyms
ADPRT, PPOL
NCBI Gene ID
Protein name
poly [ADP-ribose] polymerase 1
Protein synonyms
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADP-ribosyltransferase diphtheria toxin-like 1, ADP-ribosyltransferase NAD(+), ADPRT 1, ARTD1, DNA ADP-ribosyltransferase PARP1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, Protein poly-ADP-ribosyltransferase PARP1
Uniprot ID
Mouse ortholog
Parp1 (11545)
poly [ADP-ribose] polymerase 1 (P11103)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 5,269 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
8,524 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use