Ruboxistaurin
Ruboxistaurin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against protein kinase C beta type. In addition, it is known to target serine/threonine-protein kinase pim-1, protein kinase C gamma type, protein kinase C alpha type, serine/threonine-protein kinase pim-2, and protein kinase C delta type.
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Commercial
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 2 | 5 | — | — | 7 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | 4 | — | — | 4 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | 3 | — | — | 4 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 1 | 3 | — | — | 4 |
| Peripheral nervous system diseases | D010523 | HP_0009830 | G64 | — | — | 3 | — | — | 3 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | 3 | — | — | 3 |
| Macular edema | D008269 | — | — | — | — | 2 | — | — | 2 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | 1 | — | — | 1 |
| Edema | D004487 | HP_0000969 | R60.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 1 | — | — | — | 1 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | — | — | — | 1 |
| Hyperpigmentation | D017495 | HP_0000953 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ruboxistaurin |
| INN | ruboxistaurin |
| Description | Ruboxistaurin (proposed brand name Arxxant) is an investigational drug for diabetic retinopathy being investigated by Eli Lilly and Company. It is a member of the bisindolylmaleimide family.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 |
Identifiers
| PDB | — |
| CAS-ID | 169939-94-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL91829 |
| ChEBI ID | — |
| PubChem CID | 153999 |
| DrugBank | — |
| UNII ID | 721809WQCP (ChemIDplus, GSRS) |
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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