Roxadustat
Evrenzo (roxadustat) is a small molecule pharmaceutical. Roxadustat was first approved as Evrenzo on 2021-08-18. It has been approved in Europe to treat anemia and chronic kidney failure.
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67 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 4 | 13 | 25 | 6 | 3 | 48 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 7 | 18 | 6 | 3 | 35 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 7 | 13 | 4 | 2 | 27 |
| Syndrome | D013577 | — | — | 1 | 2 | 2 | 1 | 1 | 5 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 2 | 2 | 1 | — | 4 |
| Preleukemia | D011289 | — | — | — | 1 | 2 | 1 | — | 3 |
| Hypoxia | D000860 | — | R09.02 | — | — | — | 1 | 1 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | 1 | — | 1 |
| Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | — | — | — | 1 | — | 1 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 2 | 5 | 6 | — | — | 11 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | 4 | 3 | — | — | — | 5 |
| Dialysis | D003956 | — | — | — | 1 | — | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | — | — | — | 1 |
| St elevation myocardial infarction | D000072657 | — | — | — | 1 | — | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | — | 1 | — | — | — | 1 |
| Acute kidney injury | D058186 | — | N17 | — | 1 | — | — | — | 1 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | 1 | — | — | — | 1 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | — | — | — | 1 |
| Diabetes complications | D048909 | — | — | — | 1 | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | — | — | — | — | 9 |
| Liver failure | D017093 | — | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardio-renal syndrome | D059347 | — | — | — | — | — | — | 1 | 1 |
| Dry eye syndromes | D015352 | — | H04.12 | — | — | — | — | 1 | 1 |
| Meibomian gland dysfunction | D000080343 | — | H02.88 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Roxadustat |
| INN | roxadustat |
| Description | Roxadustat is an N-acylglycine resulting from the formal condensation of the amino group of glycine with the carboxy group of 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylic acid. It is an inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PH). It has a role as an EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor and an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor. It is a member of isoquinolines, an aromatic ether and a N-acylglycine. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12 |
Identifiers
| PDB | — |
| CAS-ID | 808118-40-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2338329 |
| ChEBI ID | — |
| PubChem CID | 11256664 |
| DrugBank | DB04847 |
| UNII ID | X3O30D9YMX (ChemIDplus, GSRS) |
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Roxadustat – AstraZeneca
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98 adverse events reported
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