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Drug ReportsRosiglitazone
Avandia(rosiglitazone)
Avaglim, Avandamet, Avandaryl, Avandia, Nyracta, Venvia (rosiglitazone) is a small molecule pharmaceutical. Rosiglitazone was first approved as Avandia on 1999-05-25. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus. The pharmaceutical is active against peroxisome proliferator-activated receptor gamma. In addition, it is known to target transient receptor potential cation channel subfamily M member 3, short transient receptor potential channel 5, and free fatty acid receptor 1.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rosiglitazone maleate
Tradename
Company
Number
Date
Products
AVANDIAWoodward Pharma ServicesN-021071 DISCN1999-05-25
3 products, RLD
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Metformin hydrochloride
+
Rosiglitazone maleate
Tradename
Company
Number
Date
Products
AVANDAMETSB PharmcoN-021410 DISCN2002-10-10
5 products, RLD
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Glimepiride
+
Rosiglitazone maleate
Tradename
Company
Number
Date
Products
AVANDARYLSB PharmcoN-021700 DISCN2005-11-23
5 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
avandametNew Drug Application2012-08-30
avandiaNew Drug Application2010-01-19
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD03: Metformin and rosiglitazone
— A10BD04: Glimepiride and rosiglitazone
— A10BG: Thiazolidinediones, blood glucose lowering drugs
— A10BG02: Rosiglitazone
HCPCS
No data
Clinical
Clinical Trials
229 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11——11—2
Diabetes mellitusD003920EFO_0000400E08-E13——11—2
Insulin resistanceD007333EFO_0002614E88.819———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRosiglitazone
INNrosiglitazone
Description
Rosiglitazone is an aminopyridine and a member of thiazolidinediones. It has a role as an insulin-sensitizing drug, a ferroptosis inhibitor and an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor. It is a conjugate acid of a rosiglitazone(1-).
Classification
Small molecule
Drug classperoxisome proliferator activiating receptor (PPAR) agonists (thiazolidene derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
Identifiers
PDB—
CAS-ID122320-73-4
RxCUI—
ChEMBL IDCHEMBL121
ChEBI ID50122
PubChem CID77999
DrugBankDB00412
UNII ID05V02F2KDG (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
RXRA
RXRA
Organism
Homo sapiens
Gene name
RXRA
Gene synonyms
NR2B1
NCBI Gene ID
Protein name
retinoic acid receptor RXR-alpha
Protein synonyms
Nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha, Retinoid X receptor alpha
Uniprot ID
Mouse ortholog
Rxra (20181)
retinoic acid receptor RXR-alpha (P28700)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Rosiglitazone
+
Glimepiride
Total medical expenditures per year (USD, in millions)
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Rosiglitazone
+
Metformin
Total medical expenditures per year (USD, in millions)
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Rosiglitazone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 30,174 documents
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Safety
Black-box Warning
Black-box warning for: Avandamet, Avandia
Adverse Events
Top Adverse Reactions
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112,177 adverse events reported
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