Avandia(rosiglitazone)
Avaglim, Avandamet, Avandaryl, Avandia, Nyracta, Venvia (rosiglitazone) is a small molecule pharmaceutical. Rosiglitazone was first approved as Avandia on 1999-05-25. It is used to treat type 2 diabetes mellitus in the USA. It has been approved in Europe to treat type 2 diabetes mellitus. The pharmaceutical is active against peroxisome proliferator-activated receptor gamma. In addition, it is known to target transient receptor potential cation channel subfamily M member 3, short transient receptor potential channel 5, and free fatty acid receptor 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nutritional and metabolic diseases | D009750 |
| endocrine system diseases | D004700 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Glimepiride
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Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDARYL | SB Pharmco | N-021700 DISCN | 2005-11-23 | 5 products, RLD |
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Metformin hydrochloride
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Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDAMET | SB Pharmco | N-021410 DISCN | 2002-10-10 | 5 products, RLD |
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Rosiglitazone maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AVANDIA | Woodward Pharma Services | N-021071 DISCN | 1999-05-25 | 3 products, RLD |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD03: Metformin and rosiglitazone
— A10BD04: Glimepiride and rosiglitazone
— A10BG: Thiazolidinediones, blood glucose lowering drugs
— A10BG02: Rosiglitazone
HCPCS
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Clinical
Clinical Trials
229 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 6 | 4 | 37 | 32 | 22 | 101 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 3 | 6 | 41 | 26 | 15 | 90 |
| Insulin resistance | D007333 | HP_0000855 | — | 2 | 7 | 4 | 6 | 8 | 25 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | 1 | 5 | 2 | 5 | 1 | 12 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 2 | 6 | 2 | 1 | 11 |
| Syndrome | D013577 | — | — | 1 | 3 | — | 3 | 1 | 7 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 2 | — | 3 | 1 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | 2 | 2 | 6 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 2 | — | 1 | 1 | 4 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 2 | 1 | 1 | 4 |
Show 24 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 5 | 4 | 4 | — | 1 | 14 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 4 | — | 4 | 8 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 3 | — | 3 | 6 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | 2 | — | 3 | 5 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | 1 | — | 1 | 3 |
| Asthma | D001249 | EFO_0000270 | J45 | 1 | 2 | 1 | — | — | 3 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 1 | — | 1 | 2 |
| Glucose metabolism disorders | D044882 | — | — | — | — | 2 | — | — | 2 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | 2 | — | — | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 4 | 3 | — | — | 4 | 10 |
| Lipodystrophy | D008060 | HP_0009125 | E88.1 | 2 | 2 | — | — | 1 | 4 |
| Malaria | D008288 | EFO_0001068 | B54 | 2 | 1 | — | — | 1 | 3 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 1 | — | — | 2 | 3 |
| Focal segmental glomerulosclerosis | D005923 | EFO_0004236 | — | 1 | 1 | — | — | — | 2 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | 1 | — | — | — | 2 |
| Hyperinsulinism | D006946 | HP_0000842 | E16.1 | — | 1 | — | — | 1 | 2 |
| Pituitary neoplasms | D010911 | — | — | — | 1 | — | — | 1 | 2 |
| Pituitary diseases | D010900 | — | E23.7 | — | 1 | — | — | 1 | 2 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | 2 | 9 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | 1 | 2 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Papillary thyroid cancer | D000077273 | — | — | 1 | — | — | — | — | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | 1 | — | — | — | — | 1 |
| Follicular adenocarcinoma | D018263 | — | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Latent autoimmune diabetes in adults | D000071698 | — | — | — | — | — | — | 2 | 2 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | — | — | 2 | 2 |
| Carcinoma | D002277 | — | C80.0 | — | — | — | — | 1 | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | — | 1 | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 1 | 1 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Carotid artery diseases | D002340 | EFO_0003781 | — | — | — | — | — | 1 | 1 |
| Atherosclerotic plaque | D058226 | HP_0031678 | I70 | — | — | — | — | 1 | 1 |
Show 15 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rosiglitazone |
| INN | rosiglitazone |
| Description | Rosiglitazone is an aminopyridine and a member of thiazolidinediones. It has a role as an insulin-sensitizing drug, a ferroptosis inhibitor and an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor. It is a conjugate acid of a rosiglitazone(1-). |
| Classification | Small molecule |
| Drug class | peroxisome proliferator activiating receptor (PPAR) agonists (thiazolidene derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 |
Identifiers
| PDB | — |
| CAS-ID | 122320-73-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL121 |
| ChEBI ID | 50122 |
| PubChem CID | 77999 |
| DrugBank | DB00412 |
| UNII ID | 05V02F2KDG (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
RXRA
RXRA
Organism
Homo sapiens
Gene name
RXRA
Gene synonyms
NR2B1
NCBI Gene ID
Protein name
retinoic acid receptor RXR-alpha
Protein synonyms
Nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha, Retinoid X receptor alpha
Uniprot ID
Mouse ortholog
Rxra (20181)
retinoic acid receptor RXR-alpha (P28700)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Rosiglitazone
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Glimepiride
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Rosiglitazone
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Metformin
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Rosiglitazone
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Avandamet, Avandia
Adverse Events
Top Adverse Reactions
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112,166 adverse events reported
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