Ropivacaine
Naropin, Ropivacaine (ropivacaine) is a small molecule pharmaceutical. Ropivacaine was first approved as Naropin on 1996-09-24. It is used to treat postoperative pain in the USA. It is known to target sodium channel protein type 5 subunit alpha.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Naropin, Ropivacaine (discontinued: Naropin, Ropivacaine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ropivacaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NAROPIN | Fresenius Kabi | N-020533 RX | 1996-09-24 | 11 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| naropin | New Drug Application | 2024-09-06 |
| naropin naropin | New Drug Application | 2018-08-02 |
| readyfusor ropivacaine | Export only | 2018-06-22 |
| ropidex | unapproved drug other | 2024-10-04 |
| ropivacaine hydrochloride | ANDA | 2025-03-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| postoperative pain | — | D010149 | G89.18 |
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| J2795 | Injection, ropivacaine hydrochloride, 1 mg |
Clinical
Clinical Trials
1881 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 11 | 25 | 43 | 172 | 277 | 522 |
| Pain | D010146 | EFO_0003843 | R52 | 8 | 7 | 14 | 41 | 61 | 128 |
| Replacement arthroplasty knee | D019645 | — | — | 3 | 6 | 5 | 41 | 40 | 92 |
| Analgesia | D000698 | — | — | — | 6 | 5 | 14 | 50 | 75 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | 3 | 2 | 4 | 23 | 38 | 70 |
| Nerve block | D009407 | — | — | 2 | 1 | 2 | 19 | 45 | 69 |
| Local anesthesia | D000772 | — | — | 2 | 3 | 5 | 16 | 38 | 63 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 4 | 3 | 27 | 29 | 61 |
| Anesthesia | D000758 | — | — | 1 | 3 | 4 | 15 | 38 | 59 |
| Conduction anesthesia | D000765 | — | — | 1 | 1 | 1 | 9 | 41 | 53 |
Show 247 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | 2 | 3 | — | 8 | 13 |
| Spinal anesthesia | D000775 | — | — | 1 | — | 1 | — | 7 | 9 |
| Synovial cyst | D013581 | — | M71.3 | — | — | 2 | — | 7 | 9 |
| Hepatectomy | D006498 | — | — | — | — | 1 | — | 8 | 9 |
| Musculoskeletal diseases | D009140 | — | — | — | 3 | 2 | — | 5 | 8 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | 1 | — | 6 | 7 |
| Wrist fractures | D000092503 | — | S52.54 | — | — | 3 | — | 4 | 7 |
| Low back pain | D017116 | — | M54.5 | — | 1 | 1 | — | 3 | 5 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | — | 1 | — | 4 | 5 |
| Post-dural puncture headache | D051299 | — | — | — | — | 1 | — | 4 | 5 |
Show 44 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | 3 | — | — | 4 | 8 |
| Traumatic stress disorders | D040921 | — | — | 1 | 2 | — | — | 2 | 5 |
| Back pain | D001416 | — | M54 | 1 | 1 | — | — | 3 | 4 |
| Nausea | D009325 | — | R11.0 | — | 1 | — | — | 3 | 4 |
| Plastic surgery procedures | D019651 | — | — | — | 1 | — | — | 2 | 3 |
| Recurrence | D012008 | — | — | — | 1 | — | — | 2 | 3 |
| Dentofacial deformities | D063169 | — | — | — | 1 | — | — | 2 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 1 | — | — | 2 | 3 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | 1 | — | — | 2 | 3 |
| Soft tissue neoplasms | D012983 | — | — | — | 1 | — | — | 1 | 2 |
Show 20 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arteriovenous fistula | D001164 | — | Q27.3 | 1 | — | — | — | 4 | 5 |
| Male circumcision | D002944 | EFO_0003953 | — | 1 | — | — | — | 4 | 5 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | 3 | 4 |
| Craniotomy | D003399 | — | — | 1 | — | — | — | 2 | 3 |
| Multiple fractures | D000069076 | — | — | 1 | — | — | — | 1 | 2 |
| Vulvar diseases | D014845 | — | — | 1 | — | — | — | 1 | 2 |
| Uterine myomectomy | D063186 | — | — | 1 | — | — | — | 1 | 2 |
| Plantar fasciitis | D036981 | EFO_1001909 | M72.2 | 1 | — | — | — | — | 1 |
| Fasciitis | D005208 | HP_0100537 | M72.9 | 1 | — | — | — | — | 1 |
| Clostridium botulinum type a | D047013 | — | — | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | — | — | 4 | 4 |
| Thoracic injuries | D013898 | — | S20-S29 | — | — | — | — | 4 | 4 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | — | 4 | 4 |
| Acrodynia | D000170 | EFO_1001756 | — | — | — | — | — | 4 | 4 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 4 | 4 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | — | — | 3 | 3 |
| Ventral hernia | D006555 | EFO_1001866 | K43 | — | — | — | — | 3 | 3 |
| Cryptorchidism | D003456 | EFO_0004562 | Q53.1 | — | — | — | — | 3 | 3 |
| Cholecystitis | D002764 | — | K81 | — | — | — | — | 3 | 3 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | — | — | 3 | 3 |
Show 209 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ropivacaine |
| INN | ropivacaine |
| Description | (S)-ropivacaine is a piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond. It has a role as a local anaesthetic. It is a piperidinecarboxamide and a ropivacaine. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C |
Identifiers
| PDB | — |
| CAS-ID | 84057-95-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1077896 |
| ChEBI ID | 8890 |
| PubChem CID | 175805 |
| DrugBank | DB00296 |
| UNII ID | 7IO5LYA57N (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SCN5A
SCN5A
Organism
Homo sapiens
Gene name
SCN5A
Gene synonyms
NCBI Gene ID
Protein name
sodium channel protein type 5 subunit alpha
Protein synonyms
cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit, hH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, sodium channel, voltage-gated, type V, alpha subunit, Voltage-gated sodium channel subunit alpha Nav1.5
Uniprot ID
Mouse ortholog
Scn5a (20271)
sodium channel protein type 5 subunit alpha (Q9JJV9)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,286 adverse events reported
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