Ropinirole
Ropinirole (ropinirole) is a small molecule pharmaceutical. Ropinirole was first approved as Requip on 1997-09-19. It is used to treat parkinson disease in the USA. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Ropinirole (discontinued: Requip, Ropinirole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| requip | New Drug Application | 2011-12-27 |
| requipxl | New Drug Application | 2009-12-18 |
| ropinirole | ANDA | 2025-11-21 |
| ropinirole hydrochloride | ANDA | 2025-05-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parkinson disease | EFO_0002508 | D010300 | G20 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
80 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ropinirole |
| INN | ropinirole |
| Description | Ropinirole is a member of indolones and a tertiary amine. It has a role as a dopamine agonist, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCN(CCC)CCc1cccc2c1CC(=O)N2 |
Identifiers
| PDB | — |
| CAS-ID | 91374-21-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL589 |
| ChEBI ID | 8888 |
| PubChem CID | 5095 |
| DrugBank | DB00268 |
| UNII ID | 030PYR8953 (ChemIDplus, GSRS) |
Target
Variants
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Financial
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Estimated US medical usage
Ropinirole
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,498 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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11,829 adverse events reported
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