Therapeutic Area | MeSH |
---|---|
musculoskeletal diseases | D009140 |
signs and symptoms pathological conditions | D013568 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
VIOXX | Merck KGaA | N-021042 DISCN | 1999-05-20 | 3 products |
VIOXX | Merck KGaA | N-021052 DISCN | 1999-05-20 | 2 products |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
dysmenorrhea | HP_0100607 | D004412 | N94.6 |
osteoarthritis | EFO_0002506 | D010003 | M15-M19 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pain | D010146 | EFO_0003843 | R52 | — | 2 | 2 | 1 | — | 5 |
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | 1 | — | 2 |
Barrett esophagus | D001471 | EFO_0000280 | K22.7 | — | — | — | 1 | — | 1 |
Analgesia | D000698 | — | — | — | — | — | 1 | — | 1 |
Acute pain | D059787 | — | R52 | — | — | — | 1 | — | 1 |
Adenomatous polyposis coli | D011125 | — | D13.91 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Postoperative pain | D010149 | — | G89.18 | — | — | 5 | — | — | 5 |
Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | 3 | — | — | 4 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 2 | — | — | 2 |
Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | 1 | — | — | 1 |
Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | 1 | — | — | 1 |
Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | — | 1 |
Colorectal neoplasms | D015179 | — | — | — | — | 1 | — | — | 1 |
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Tooth extraction | D014081 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Antiphospholipid syndrome | D016736 | EFO_0002689 | D68.61 | — | — | — | — | 1 | 1 |
Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 1 | 1 |
Drug common name | Rofecoxib |
INN | rofecoxib |
Description | Rofecoxib is a butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. It has a role as a cyclooxygenase 2 inhibitor, a non-steroidal anti-inflammatory drug and an analgesic. It is a sulfone and a butenolide. |
Classification | Small molecule |
Drug class | cyclooxygenase-2 inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 |
PDB | — |
CAS-ID | 162011-90-7 |
RxCUI | — |
ChEMBL ID | CHEMBL122 |
ChEBI ID | 8887 |
PubChem CID | 5090 |
DrugBank | DB00533 |
UNII ID | 0QTW8Z7MCR (ChemIDplus, GSRS) |