Rocuronium
Rocuronium (rocuronium) is a small molecule pharmaceutical. Rocuronium was first approved as Zemuron on 1994-03-17.
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Rocuronium (discontinued: Rocuronium, Zemuron)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| rocuronium | ANDA | 2024-03-19 |
| rocuronium bromide | ANDA | 2024-10-30 |
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Clinical
Clinical Trials
660 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromuscular blockade | D019148 | — | — | 1 | 9 | 10 | 48 | 54 | 122 |
| Anesthesia | D000758 | — | — | — | 2 | 11 | 20 | 36 | 68 |
| General anesthesia | D000768 | — | — | 1 | 10 | 14 | 3 | 29 | 56 |
| Postoperative pain | D010149 | — | G89.18 | — | 2 | 3 | 11 | 22 | 37 |
| Muscle relaxation | D009126 | — | — | 2 | 3 | 3 | 9 | 8 | 23 |
| Intratracheal intubation | D007442 | — | — | — | 1 | 1 | 5 | 12 | 19 |
| Delayed emergence from anesthesia | D055191 | — | — | 1 | — | — | 7 | 10 | 18 |
| Muscle hypotonia | D009123 | HP_0001319 | — | 3 | 1 | 2 | 4 | 7 | 16 |
| Postoperative complications | D011183 | — | — | — | — | — | 4 | 11 | 15 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | 7 | 7 | 15 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart arrest | D006323 | EFO_0009492 | I46 | — | 2 | 1 | — | 2 | 5 |
| Nerve block | D009407 | — | — | — | — | 1 | — | 3 | 4 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | 1 | — | 2 | 3 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | — | 1 | — | 2 | 3 |
| Myalgia | D063806 | HP_0003326 | M79.1 | — | — | 1 | — | 2 | 3 |
| Heart rate | D006339 | EFO_0004326 | — | — | 1 | 1 | — | 1 | 2 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | 1 | — | — | 1 |
| Spinal fusion | D013123 | — | — | — | — | 1 | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | 1 | — | — | 1 |
| Colectomy | D003082 | — | — | — | 1 | 1 | — | — | 1 |
Show 14 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | 1 | — | — | 2 | 3 |
| Circulating neoplastic cells | D009360 | — | — | — | 1 | — | — | 1 | 2 |
| Out-of-hospital cardiac arrest | D058687 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| High-frequency jet ventilation | D006611 | — | — | 1 | — | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Spinal fractures | D016103 | EFO_0003902 | S12 | 1 | — | — | — | — | 1 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | — | — | — | 6 | 6 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 6 | 6 |
| Inhalation anesthesia | D000769 | — | — | — | — | — | — | 5 | 5 |
| Neuromuscular monitoring | D061886 | — | — | — | — | — | — | 5 | 5 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | — | — | — | 4 | 4 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 4 | 4 |
| Hysterectomy | D007044 | EFO_0003881 | — | — | — | — | — | 4 | 4 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 4 | 4 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 3 | 3 |
| Thyroidectomy | D013965 | — | — | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rocuronium |
| INN | rocuronium bromide |
| Description | Rocuronium bromide is the organic bromide salt of a 5alpha androstane compound having 3alpha-hydroxy-, 17beta-acetoxy-, 2beta-morpholino- and 16beta-N-allyllyrrolidinium substituents. It has a role as a neuromuscular agent and a muscle relaxant. It is an organic bromide salt and a quaternary ammonium salt. It contains a rocuronium. It derives from a hydride of a 5alpha-androstane. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents; quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 143558-00-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201244 |
| ChEBI ID | 8884 |
| PubChem CID | 441351 |
| DrugBank | DB00728 |
| UNII ID | I65MW4OFHZ (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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6,910 adverse events reported
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