Exelon(rivastigmine)
Exelon, Nimvastid, Prometax, Rivastigmine (rivastigmine) is a small molecule pharmaceutical. Rivastigmine was first approved as Exelon on 1998-05-11. It is used to treat alzheimer disease in the USA. It has been approved in Europe to treat alzheimer disease, dementia, and parkinson disease. The pharmaceutical is active against cholinesterase and acetylcholinesterase.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Exelon (generic drugs available since 2007-10-22, discontinued: Exelon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alzheimer disease | EFO_0000249 | D000544 | F03 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
103 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 4 | 12 | 20 | 15 | 52 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 3 | 6 | — | 9 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | 1 | 5 | 1 | 7 |
| Delirium | D003693 | — | R41.0 | 1 | 1 | 3 | 3 | — | 7 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | 2 | 1 | 5 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | 2 | 1 | — | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 2 | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | 2 | — | 2 |
| Neurocognitive disorders | D019965 | — | F09 | — | — | — | 1 | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dementia | D003704 | EFO_0003862 | F03 | — | 1 | 3 | — | 5 | 9 |
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | — | 1 | 1 | — | — | 2 |
| Vascular dementia | D015140 | — | F01 | — | — | 2 | — | — | 2 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Depression | D003863 | — | F33.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Neurobehavioral manifestations | D019954 | EFO_0004364 | — | — | — | 1 | — | — | 1 |
| Cognition disorders | D003072 | — | — | — | — | 1 | — | — | 1 |
| Apathy | D057565 | HP_0000741 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Down syndrome | D004314 | EFO_0001064 | Q90 | 1 | 1 | — | — | 1 | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 3 | — | — | — | — | 3 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Central nervous system diseases | D002493 | HP_0002011 | G96.9 | 1 | — | — | — | 1 | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Biological availability | D001682 | — | — | 1 | — | — | — | — | 1 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | — | 1 |
| Hallucinations | D006212 | HP_0000738 | F06.0 | 1 | — | — | — | — | 1 |
| Psychotic disorders | D011618 | — | F20.81 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy aging | D000073656 | — | — | — | — | — | — | 2 | 2 |
| Brain diseases | D001927 | HP_0001298 | G93.40 | — | — | — | — | 2 | 2 |
| Nervous system diseases | D009422 | — | G00-G99 | — | — | — | — | 2 | 2 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | — | — | — | 2 | 2 |
| Deep brain stimulation | D046690 | — | — | — | — | — | — | 1 | 1 |
| Lewy body disease | D020961 | EFO_0006792 | G31.83 | — | — | — | — | 1 | 1 |
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | — | — | 1 | 1 |
| Tauopathies | D024801 | — | — | — | — | — | — | 1 | 1 |
| Frailty | D000073496 | — | R53.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rivastigmine |
| INN | rivastigmine |
| Description | Rivastigmine is a carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, a neuroprotective agent and a cholinergic drug. It is a carbamate ester and a tertiary amino compound. It is a conjugate base of a rivastigmine(1+). |
| Classification | Small molecule |
| Drug class | cholinesterase inhibitors (physostigmine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(C)C(=O)Oc1cccc([C@H](C)N(C)C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 123441-03-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL636 |
| ChEBI ID | 8874 |
| PubChem CID | 77991 |
| DrugBank | DB00989 |
| UNII ID | PKI06M3IW0 (ChemIDplus, GSRS) |
Target
Agency Approved
BCHE
BCHE
ACHE
ACHE
Organism
Homo sapiens
Gene name
BCHE
Gene synonyms
CHE1
NCBI Gene ID
Protein name
cholinesterase
Protein synonyms
Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, cholinesterase (serum) 2, cholinesterase 1, Pseudocholinesterase
Uniprot ID
Mouse ortholog
Bche (12038)
cholinesterase (Q543J3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
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Exelon – Novartis
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Tabular view
Estimated US medical usage
Rivastigmine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,028 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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16,941 adverse events reported
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