Exelon(rivastigmine)
Exelon, Nimvastid, Prometax, Rivastigmine (rivastigmine) is a small molecule pharmaceutical. Rivastigmine was first approved as Exelon on 1998-05-11. It is used to treat alzheimer disease in the USA. It has been approved in Europe to treat alzheimer disease, dementia, and parkinson disease. The pharmaceutical is active against cholinesterase and acetylcholinesterase.
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Events Timeline
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YTD
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2Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Exelon, Rivastigmine (discontinued: Exelon, Rivastigmine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| exelon | New Drug Application | 2024-05-08 |
| rivastigmine | ANDA | 2024-09-21 |
| rivastigmine tartrate | ANDA | 2025-03-03 |
| rivastigmine transdermal system | ANDA | 2025-04-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alzheimer disease | EFO_0000249 | D000544 | F03 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
109 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | 8 | 14 | 2 | 24 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 4 | 4 | — | 8 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | 3 | 4 | — | 7 |
| Delirium | D003693 | — | R41.0 | — | — | 2 | 2 | — | 4 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | 1 | 1 | — | 2 |
| Emergence delirium | D000071257 | — | — | — | — | 1 | 1 | — | 2 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | 1 | 1 | — | 2 |
| Traumatic brain injuries | D000070642 | — | S06 | — | — | 1 | 1 | — | 2 |
| Brain injuries | D001930 | — | S06.9 | — | — | 1 | 1 | — | 2 |
| Cognition disorders | D003072 | — | — | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vascular dementia | D015140 | — | F01 | — | — | 2 | — | — | 2 |
| Neurobehavioral manifestations | D019954 | EFO_0004364 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rivastigmine |
| INN | rivastigmine |
| Description | Rivastigmine is a carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, a neuroprotective agent and a cholinergic drug. It is a carbamate ester and a tertiary amino compound. It is a conjugate base of a rivastigmine(1+). |
| Classification | Small molecule |
| Drug class | cholinesterase inhibitors (physostigmine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(C)C(=O)Oc1cccc([C@H](C)N(C)C)c1 |
Identifiers
| PDB | — |
| CAS-ID | 123441-03-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL636 |
| ChEBI ID | 8874 |
| PubChem CID | 77991 |
| DrugBank | DB00989 |
| UNII ID | PKI06M3IW0 (ChemIDplus, GSRS) |
Target
Agency Approved
BCHE
BCHE
ACHE
ACHE
Organism
Homo sapiens
Gene name
BCHE
Gene synonyms
CHE1
NCBI Gene ID
Protein name
cholinesterase
Protein synonyms
Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, cholinesterase (serum) 2, cholinesterase 1, Pseudocholinesterase
Uniprot ID
Mouse ortholog
Bche (12038)
cholinesterase (Q543J3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Exelon – Novartis
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Tabular view
Estimated US medical usage
Rivastigmine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,787 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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18,872 adverse events reported
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