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Drug ReportsRitonavir
Norvir(ritonavir)
Kaletra, Norvir, Paxlovid, Ritonavir, Technivie, Viekira, Viekirax (ritonavir) is a small molecule pharmaceutical. Ritonavir was first approved as Norvir on 1996-03-01. It is used to treat acquired immunodeficiency syndrome in the USA. It has been approved in Europe to treat chronic hepatitis c and HIV infections. It is known to target UDP-glucuronosyltransferase 1A1, cytochrome P450 3A5, and cytochrome P450 3A4.
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COVID-19
Case Study: COVID-19
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
urogenital diseasesD000091642
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Norvir, Ritonavir (discontinued: Norvir, Ritonavir)
Combinations
Kaletra, Lopinavir ritonavir, Paxlovid (discontinued: Kaletra, Technivie, Viekira)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lopinavir
+
Ritonavir
Tradename
Company
Number
Date
Products
KALETRAAbbVieN-021251 RX2000-09-15
1 products, RLD, RS
KALETRAAbbVieN-021906 RX2005-10-28
2 products, RLD, RS
Show 1 discontinued
Ritonavir
Tradename
Company
Number
Date
Products
NORVIRAbbVieN-022417 RX2010-02-10
1 products, RLD, RS
NORVIRAbbVieN-209512 RX2017-06-07
1 products, RLD, RS
Show 3 discontinued
Ombitasvir
+
Paritaprevir
+
Ritonavir
Tradename
Company
Number
Date
Products
TECHNIVIEAbbVieN-207931 DISCN2015-07-24
1 products, RLD
Hide discontinued
Dasabuvir sodium
+
Ombitasvir
+
Paritaprevir
+
Ritonavir
Tradename
Company
Number
Date
Products
VIEKIRA PAK (COPACKAGED)AbbVieN-206619 DISCN2014-12-19
1 products, RLD
VIEKIRA XRAbbVieN-208624 DISCN2016-07-22
1 products, RLD
Hide discontinued
Nirmatrelvir
+
Ritonavir
Tradename
Company
Number
Date
Products
PAXLOVID (COPACKAGED)PfizerN-217188 RX2023-05-25
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
kaletraNew Drug Application2023-07-06
lopinavir and ritonavirANDA2023-10-20
lopinavir-ritonavirANDA2020-11-18
norvirNew Drug Application2024-07-03
paxlovidNew Drug Application2025-07-09
ritonavirANDA2025-06-05
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Dasabuvir Sodium / Ombitasvir / Paritaprevir / Ritonavir, Viekira Xr, Abbvie
93332042035-01-02DPU-1889
97441702035-01-02DPU-1889
101053652035-01-02DPU-1889
102015412032-05-17DP
102015842032-05-17U-1889
Dasabuvir Sodium / Ombitasvir / Paritaprevir / Ritonavir, Viekira Pak (Copackaged), Abbvie
96298412033-10-18DPU-1753
102015422033-10-18DPU-1753
84661592032-09-04U-1637
84923862032-09-04U-1840
86801062032-09-04U-1637
86859842032-09-04U-1840
86919382032-04-13DS, DP
86860262031-06-09DP
84205962031-04-10DS, DP
90444802031-04-10U-1638
90063872030-06-10U-1687
86425382029-09-10DS, DPU-1638
81881042029-05-17DS, DPU-1636
85012382028-12-19DS, DPU-1636
91395362028-11-09U-1753
82683492024-08-25DP
83990152024-08-25DP
ATC Codes
J: Antiinfectives for systemic use
J05: Antivirals for systemic use
J05A: Direct acting antivirals
J05AE: Protease inhibitors, direct acting antivirals
J05AE03: Ritonavir
J05AP: Antivirals for treatment of hcv infections
J05AP52: Dasabuvir, ombitasvir, paritaprevir and ritonavir
J05AP53: Ombitasvir, paritaprevir and ritonavir
J05AR: Antivirals for treatment of hiv infections, combinations
J05AR10: Lopinavir and ritonavir
J05AR23: Atazanavir and ritonavir
J05AR26: Darunavir and ritonavir
HCPCS
No data
Clinical
Clinical Trials
1178 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2091153153130109602
InfectionsD007239EFO_00005441737572225154
Acquired immunodeficiency syndromeD000163EFO_0000765B202133433031153
Hepatitis cD006526B19.22242431329141
HepatitisD006505K75.9144944729136
Covid-19D000086382U07.11141431141128
HivD006678O98.72217264018119
Hepatitis aD006506EFO_0007305B1573941626113
Healthy volunteers/patients98274111
Chronic hepatitis cD019698EFO_0004220B18.263635922103
Show 59 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C808310
Liver diseasesD008107EFO_0001421K70-K77415
Viral pneumoniaD011024EFO_0007541J12.9134
Prostatic neoplasmsD011471C61314
CoronavirusD017934123
Breast neoplasmsD001943EFO_0003869C50213
Immunocompromised hostD016867D84.9123
GlioblastomaD005909EFO_0000515122
DiseaseD004194EFO_0000408R6922
Castration-resistant prostatic neoplasmsD064129112
Show 23 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD010599415
Hepatic insufficiencyD04855055
Biological availabilityD00168255
HypertensionD006973EFO_0000537I10213
Pulmonary arterial hypertensionD000081029213
Insulin resistanceD007333EFO_0002614E88.819213
AsthmaD001249EFO_0000270J45112
Neoplasm metastasisD009362EFO_000970822
Liver failureD017093K72.922
Therapeutic equivalencyD013810112
Show 34 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E1322
Female genital diseasesD005831EFO_0009549N8511
Genital diseasesD00009166211
Wasting syndromeD01928211
CachexiaD002100R6411
Heart failureD006333EFO_0003144I5011
MenorrhagiaD008595EFO_0003945N92.011
Hemophilia aD006467EFO_0007267D6611
PainD010146EFO_0003843R5211
Down syndromeD004314EFO_0001064Q9011
Show 37 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRitonavir
INNritonavir
Description
Ritonavir is an L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. It has a role as an antiviral drug, a HIV protease inhibitor, an environmental contaminant and a xenobiotic. It is a member of 1,3-thiazoles, a L-valine derivative, a carbamate ester, a member of ureas and a carboxamide.
Classification
Small molecule
Drug classantivirals: HIV protease inhibitors (saquinavir type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1
Identifiers
PDB
CAS-ID155213-67-5
RxCUI
ChEMBL IDCHEMBL163
ChEBI ID45409
PubChem CID392622
DrugBankDB00503
UNII IDO3J8G9O825 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP3A4
CYP3A4
Organism
Homo sapiens
Gene name
CYP3A4
Gene synonyms
CYP3A3
NCBI Gene ID
Protein name
cytochrome P450 3A4
Protein synonyms
1,4-cineole 2-exo-monooxygenase, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase (sulfoxide-forming), Albendazole sulfoxidase, Cholesterol 25-hydroxylase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, cytochrome P450, family 3, subfamily A, polypeptide 4, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, Cytochrome P450-PCN1, glucocorticoid-inducible P450, Nifedipine oxidase, P450-III, steroid inducible, Quinine 3-monooxygenase, taurochenodeoxycholate 6-alpha-hydroxylase
Uniprot ID
Mouse ortholog
Variants
No data
Financial
Revenue by drug
$
£
Viekira AbbVie
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Kaletra AbbVie
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Norvir AbbVie
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Paxlovid Pfizer
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Estimated US medical usage
Ritonavir
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Lopinavir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Ritonavir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 46,631 documents
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Safety
Black-box Warning
Black-box warning for: Norvir, Paxlovid, Ritonavir
Adverse Events
Top Adverse Reactions
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103,312 adverse events reported
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