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Drug ReportsRitonavir
Norvir(ritonavir)
Kaletra, Norvir, Paxlovid, Ritonavir, Technivie, Viekira, Viekirax (ritonavir) is a small molecule pharmaceutical. Ritonavir was first approved as Norvir on 1996-03-01. It is used to treat acquired immunodeficiency syndrome in the USA. It has been approved in Europe to treat chronic hepatitis c and HIV infections. It is known to target UDP-glucuronosyltransferase 1A1, cytochrome P450 3A5, and cytochrome P450 3A4.
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COVID-19
Case Study: COVID-19
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
urogenital diseasesD000091642
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Norvir, Ritonavir (discontinued: Norvir, Ritonavir)
Combinations
Kaletra, Lopinavir ritonavir, Paxlovid (discontinued: Kaletra, Technivie, Viekira)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Lopinavir
+
Ritonavir
Tradename
Company
Number
Date
Products
KALETRAAbbVieN-021251 RX2000-09-15
1 products, RLD, RS
KALETRAAbbVieN-021906 RX2005-10-28
2 products, RLD, RS
Show 1 discontinued
Ritonavir
Tradename
Company
Number
Date
Products
NORVIRAbbVieN-022417 RX2010-02-10
1 products, RLD, RS
NORVIRAbbVieN-209512 RX2017-06-07
1 products, RLD, RS
Show 3 discontinued
Ombitasvir
+
Paritaprevir
+
Ritonavir
Tradename
Company
Number
Date
Products
TECHNIVIEAbbVieN-207931 DISCN2015-07-24
1 products, RLD
Hide discontinued
Dasabuvir sodium
+
Ombitasvir
+
Paritaprevir
+
Ritonavir
Tradename
Company
Number
Date
Products
VIEKIRA PAK (COPACKAGED)AbbVieN-206619 DISCN2014-12-19
1 products, RLD
VIEKIRA XRAbbVieN-208624 DISCN2016-07-22
1 products, RLD
Hide discontinued
Nirmatrelvir
+
Ritonavir
Tradename
Company
Number
Date
Products
PAXLOVID (COPACKAGED)PfizerN-217188 RX2023-05-25
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
kaletraNew Drug Application2023-07-06
lopinavir and ritonavirANDA2023-10-20
norvirNew Drug Application2024-07-03
paxlovidNew Drug Application2026-02-19
ritonavirANDA2026-03-11
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acquired immunodeficiency syndromeEFO_0000765D000163B20
hepatitis c—D006526B19.2
chronic hepatitis cEFO_0004220D019698B18.2
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Dasabuvir Sodium / Ombitasvir / Paritaprevir / Ritonavir, Viekira Xr, Abbvie
93332042035-01-02DPU-1889
97441702035-01-02DPU-1889
101053652035-01-02DPU-1889
102015412032-05-17DP
102015842032-05-17U-1889
Dasabuvir Sodium / Ombitasvir / Paritaprevir / Ritonavir, Viekira Pak (Copackaged), Abbvie
96298412033-10-18DPU-1753
102015422033-10-18DPU-1753
84661592032-09-04U-1637
84923862032-09-04U-1840
86801062032-09-04U-1637
86859842032-09-04U-1840
86919382032-04-13DS, DP
86860262031-06-09DP
84205962031-04-10DS, DP
90444802031-04-10U-1638
90063872030-06-10U-1687
86425382029-09-10DS, DPU-1638
81881042029-05-17DS, DPU-1636
85012382028-12-19DS, DPU-1636
91395362028-11-09U-1753
82683492024-08-25DP
83990152024-08-25DP
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AE: Protease inhibitors, direct acting antivirals
— J05AE03: Ritonavir
— J05AP: Antivirals for treatment of hcv infections
— J05AP52: Dasabuvir, ombitasvir, paritaprevir and ritonavir
— J05AP53: Ombitasvir, paritaprevir and ritonavir
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR10: Lopinavir and ritonavir
— J05AR23: Atazanavir and ritonavir
— J05AR26: Darunavir and ritonavir
HCPCS
No data
Clinical
Clinical Trials
1194 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2084148151131101582
Acquired immunodeficiency syndromeD000163EFO_0000765B202728463632165
Covid-19D000086382—U07.11641421039130
HivD006678—O98.72318274218123
Hepatitis cD006526—B19.22127401427122
Healthy volunteers/patients———982—74111
InfectionsD007239EFO_0000544—152036111898
Chronic hepatitis cD019698EFO_0004220B18.26272992189
HepatitisD006505—K75.9472152356
Hepatitis aD006506EFO_0007305B15241942350
Show 58 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic hepatitis bD019694EFO_0004239B18.141414—231
FibrosisD005355———35—210
Liver cirrhosisD008103EFO_0001422K74.0—35—29
Virus diseasesD014777—B34123—39
Severe acute respiratory syndromeD045169EFO_0000694J12.81123—38
Respiratory distress syndromeD012128EFO_1000637J80121—36
Chronic hepatitis dD019701———32——5
Hepatitis dD003699EFO_0007304——32——5
Respiratory tract infectionsD012141—J06.9112——4
SarcomaD012509——131——4
Show 15 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C8085———11
Prostatic neoplasmsD011471—C6143———6
Viral pneumoniaD011024EFO_0007541J12.9—2——35
Breast neoplasmsD001943EFO_0003869C5033———5
Neoplasm metastasisD009362EFO_0009708—32———4
Non-small-cell lung carcinomaD002289——33———4
Liver diseasesD008107EFO_0001421K70-K7722———4
CoronavirusD017934———1——23
Brain neoplasmsD001932EFO_0003833C71—3———3
RecurrenceD012008——21——13
Show 83 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD010599——4———15
Hepatic insufficiencyD048550——5————5
Biological availabilityD001682——5————5
Pulmonary arterial hypertensionD000081029——2———13
Substance-related disordersD019966EFO_0003890F132————2
HypertensionD006973EFO_0000537I101———12
AsthmaD001249EFO_0000270J451———12
Insulin resistanceD007333EFO_0002614E88.8191———12
Adolescent behaviorD000294——1———12
Therapeutic equivalencyD013810——1———12
Show 31 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13————22
Female genital diseasesD005831EFO_0009549N85————11
Genital diseasesD000091662——————11
Wasting syndromeD019282——————11
CachexiaD002100—R64————11
HemorrhageD006470MP_0001914R58————11
Heart failureD006333EFO_0003144I50————11
MenorrhagiaD008595EFO_0003945N92.0————11
Hemophilia aD006467EFO_0007267D66————11
PainD010146EFO_0003843R52————11
Show 35 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRitonavir
INNritonavir
Description
Ritonavir is an L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. It has a role as an antiviral drug, a HIV protease inhibitor, an environmental contaminant and a xenobiotic. It is a member of 1,3-thiazoles, a L-valine derivative, a carbamate ester, a member of ureas and a carboxamide.
Classification
Small molecule
Drug classantivirals: HIV protease inhibitors (saquinavir type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1
Identifiers
PDB—
CAS-ID155213-67-5
RxCUI—
ChEMBL IDCHEMBL163
ChEBI ID45409
PubChem CID392622
DrugBankDB00503
UNII IDO3J8G9O825 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP3A4
CYP3A4
Organism
Homo sapiens
Gene name
CYP3A4
Gene synonyms
CYP3A3
NCBI Gene ID
1576
Protein name
cytochrome P450 3A4
Protein synonyms
1,4-cineole 2-exo-monooxygenase, 1,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase (sulfoxide-forming), Albendazole sulfoxidase, Cholesterol 25-hydroxylase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, cytochrome P450, family 3, subfamily A, polypeptide 4, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, Cytochrome P450-PCN1, glucocorticoid-inducible P450, Nifedipine oxidase, P450-III, steroid inducible, Quinine 3-monooxygenase, taurochenodeoxycholate 6-alpha-hydroxylase
Uniprot ID
P08684
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Viekira – AbbVie
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Kaletra – AbbVie
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Norvir – AbbVie
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Paxlovid – Pfizer
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Estimated US medical usage
Ritonavir
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Lopinavir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Ritonavir
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
Black-box warning for: Norvir, Paxlovid, Ritonavir
Adverse Events
Top Adverse Reactions
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105,510 adverse events reported
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