Litfulo(ritlecitinib)
Litfulo (ritlecitinib) is a small molecule pharmaceutical. Ritlecitinib was first approved as Litfulo on 2023-06-23. It is used to treat alopecia areata in the USA. It has been approved in Europe to treat alopecia areata.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Litfulo
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| litfulo | New Drug Application | 2024-07-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| alopecia areata | EFO_0004192 | D000506 | L63 |
Agency Specific
FDA
EMA
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Patent Expiration
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Clinical
Clinical Trials
47 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alopecia areata | D000506 | EFO_0004192 | L63 | 1 | 4 | 2 | — | 4 | 10 |
| Alopecia | D000505 | HP_0002293 | L64 | 1 | 4 | 2 | — | 4 | 10 |
| Vitiligo | D014820 | EFO_0004208 | L80 | — | 1 | 3 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 2 | — | — | — | 2 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 2 | — | — | — | 2 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | 1 | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | — | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | 1 | — | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Celiac disease | D002446 | EFO_0001060 | K90.0 | — | 1 | — | — | — | 1 |
| Mycoses | D009181 | — | B35-B49 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 23 | — | — | — | — | 23 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ritlecitinib |
| INN | ritlecitinib |
| Description | Ritlecitinib is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a [(3R,6S)-6-methyl-1-(prop-2-enoyl)piperidin-3-yl]amino group. It is a dual inhibitor of Janus kinase 3 and the TEC family of tyrosine kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antirheumatic drug, an anti-inflammatory drug and an immunosuppressive agent. It is a pyrrolopyrimidine, a N-acylpiperidine, a secondary amino compound, a member of acrylamides and a tertiary carboxamide. It is a conjugate base of a ritlecitinib(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C |
Identifiers
| PDB | — |
| CAS-ID | 1792180-81-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4085457 |
| ChEBI ID | — |
| PubChem CID | 118115473 |
| DrugBank | DB14924 |
| UNII ID | 2OYE00PC25 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Safety
Black-box Warning
Black-box warning for: Litfulo
Adverse Events
Top Adverse Reactions
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709 adverse events reported
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