Rimonabant
Acomplia, Zimulti (rimonabant) is a small molecule pharmaceutical. Rimonabant was first approved as Acomplia on 2006-06-19. It has been approved in Europe to treat obesity. It is known to target cannabinoid receptor 1 and G-protein coupled receptor 55.
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 17 | — | — | 18 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | 10 | — | — | 10 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | 7 | — | — | 7 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | — | 5 | — | — | 5 |
| Dyslipidemias | D050171 | HP_0003119 | — | — | — | 5 | — | — | 5 |
| Weight loss | D015431 | HP_0001824 | — | — | — | 3 | — | — | 3 |
| Overweight | D050177 | — | E66.3 | — | — | 2 | — | — | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | 2 | — | — | 2 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 2 | — | — | 2 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 1 | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | — | 1 | — | — | — | 1 |
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Drug
General
| Drug common name | Rimonabant |
| INN | rimonabant |
| Description | Rimonabant is a carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation. It has a role as an anti-obesity agent, a CB1 receptor antagonist and an appetite depressant. It is a member of pyrazoles, a dichlorobenzene, a carbohydrazide, an amidopiperidine and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | cannabinol derivatives: CB (e.g., CB, CB2, etc.) cannabinoid receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c(C(=O)NN2CCCCC2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 168273-06-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL111 |
| ChEBI ID | 34967 |
| PubChem CID | 104850 |
| DrugBank | DB06155 |
| UNII ID | RML78EN3XE (ChemIDplus, GSRS) |
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