Rifamycin
Aemcolo (rifamycin) is a small molecule pharmaceutical. Rifamycin was first approved as Aemcolo on 2018-11-16. It is known to target solute carrier organic anion transporter family member 1A2, solute carrier organic anion transporter family member 2B1, solute carrier organic anion transporter family member 1B1, and solute carrier organic anion transporter family member 1B3.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Rifamycin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AEMCOLO | RedHill Biopharma | N-210910 DISCN | 2018-11-16 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aemcolo | New Drug Application | 2024-12-11 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
RIFAMYCIN SODIUM, AEMCOLO, REDHILL | |||
| 2028-11-16 | GAIN | ||
| 2023-11-16 | NCE | ||
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA13: Rifamycin
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06A: Antibiotics for topical use
— D06AX: Other antibiotics for topical use in atc
— D06AX15: Rifamycin
J: Antiinfectives for systemic use
— J04: Antimycobacterials
— J04A: Drugs for treatment of tuberculosis
— J04AB: Antibiotics, antitubercular
— J04AB03: Rifamycin
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA16: Rifamycin
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA12: Rifamycin
HCPCS
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Clinical
Clinical Trials
30 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Rifamycin |
| INN | rifamide |
| Description | Rifamycin SV is a member of the class of rifamycins that exhibits antibiotic and antitubercular properties. It has a role as a bacterial metabolite, an antimicrobial agent and an antitubercular agent. It is a member of rifamycins, an acetate ester, a cyclic ketal, a lactam, a macrocycle, a polyphenol and an organic heterotetracyclic compound. It is a conjugate acid of a rifamycin SV(1-). |
| Classification | Small molecule |
| Drug class | antibiotics (Streptomyces strain); antibiotics (rifamycin derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C |
Identifiers
| PDB | — |
| CAS-ID | 6998-60-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL437765 |
| ChEBI ID | 29673 |
| PubChem CID | 6324616 |
| DrugBank | DB11753 |
| UNII ID | TS121H7U7E (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SLCO1A2
SLCO1A2
SLCO2B1
SLCO2B1
SLCO1B1
SLCO1B1
SLCO1B3
SLCO1B3
Organism
Homo sapiens
Gene name
SLCO1A2
Gene synonyms
OATP, OATP1, OATP1A2, SLC21A3
NCBI Gene ID
Protein name
solute carrier organic anion transporter family member 1A2
Protein synonyms
OATP-1, OATP-A, organic anion transporting polypeptide A, Organic anion-transporting polypeptide 1, Sodium-independent organic anion transporter, solute carrier family 21 (organic anion transporter), member 3, Solute carrier family 21 member 3
Uniprot ID
Mouse ortholog
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Trends
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Safety
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Adverse Events
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233 adverse events reported
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